Vaccination Support


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Detoxification is also aided by binders in the intestines and tissues that help the body eliminate toxins more efficiently.  Binders can range from humic and fulvic acid, charcoal, to chlorella (an algae). Liver support and kidney support, which are two primary organs involved in elimination of toxins, can be supported by glutathione, dandelion, quercetin, and taurine to support bile acid function.  ToxinPul™ (Researched Nutritionals) combines binders with detoxification support of the liver and kidneys in order to support the body properly processing the ingredients in the vaccines.  Since some vaccines contain aluminum as an adjuvant, silica was included in the product to aid the body in aluminum removal.


Autoimmunity and Inflammatory Syndrome Post-Vaccination

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Evidence from both clinical and experimental research models have shown post-vaccine autoimmunity.25   In 2011, the term autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to encompass vaccine-induced and adjuvant-induced autoimmunity and autoinflammatory diseases.26  One of the primary adjuvants is aluminum, and it  has been associated with adverse immune events, including autoimmunity.26  In addition to the vaccine and adjuvants, other things contribute to the development of autoimmunity in a complex interplay of genetics and environment such as other infections, dysbiosis, and potentially underlying immune imbalance.2,27  The combination of vaccines and/or adjuvants can also contribute to an innate inflammatory response termed an autoinflammatory response.2


Post Vaccine:  Immune Modulation

It takes approximately two weeks after vaccination for an immune response to develop for some vaccines such as the COVID-19 vaccines.28  For vaccine efficacy this is important to let the body develop these antibodies and cellular immune response.  The concern is the long-term development of autoimmune and inflammatory issues in those people who are susceptible based on environmental and genetic factors.  People with underlying autoimmune disease or chronic infections such as Borrelia are more likely to develop autoimmune reactions.  Women are also at increased risk of the ASIA post-vaccine syndrome.  Dysbiosis increases the risk of autoimmune disease because it is a pro-inflammatory state that drives up the Th17 cells and decreases the T-regulatory cells.

With this information, after immunity has developed, it is important to be able to balance and support the immune system.  This includes decreasing inflammation to decrease Th17 and increase Treg cells to decrease autoimmune disease development.  It also includes increasing Th1 to fight infections and decrease Th2 to decrease development of allergic reactions.

I recommend after two weeks, adding immune modulation with Transfer Factor Multi-Immune™ (TFMI) and CytoQuel®.  TFMI contains transfer factors released by T-helper cells to support a strong cellular immune response.  TFMI has research showing an increase in cells supporting both an innate and adaptive Th1 immune response.29   It also contains a mix of medicinal mushrooms, astragalus, zinc, selenium, and antioxidant herbs that help modulate and support the immune system.  Unpublished research shows an increase in IL-10, which supports T-regulatory cell function to decrease the development of autoimmune disease.29

CytoQuel® contains CurcuWin (highly absorbable curcumin), resveratrol, EGCG, tocotrienols, and NAC.  Published research shows a decrease in pain and activating cytokines.30 Adding CytoQuel® two weeks post vaccine can help modulate the potential ASIA response.


Conclusion

For vaccination to be successful, it has to lead to a strong effective immune reaction while also having a high safety profile.  Since various factors from age to nutritional deficiency can weaken immune responses, it is important to support a person’s immune system as well as possible before vaccination.  Being able to detoxify and safely process the vaccine can also be supported by natural supplementation.  Long-term risks of vaccines can involve autoimmune and autoinflammatory conditions, so I recommend targeted nutraceutical support for the patient.

Recommendations Summary

  1. Begin one week before, through at least two weeks after vaccination
    1. Physician’s Multi™
    1. C-RLA™
    1. ToxinPul™
    1. Tri-Fortify® Liposomal Glutathione
  2. Begin two weeks after vaccination
    1. Transfer Factor Multi-Immune™
    1. CytoQuel®

For ongoing immune and detoxification support, the physician may recommend continuing nutraceutical support.


References

  1. Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments [published correction appears in Nat Rev Immunol. 2021 Jan 5;:]. Nat Rev Immunol. 2021;21(2):83-100. 
  2. Watad A. et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases. Clin Immunol. 2019 Jun;203:1-8.
  3. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html
  4. Vetter V. et al. Understanding modern-day vaccines: what you need to know. Ann Med. 2018 Mar;50(2):110-120.
  5. Zimmermann P, Curtis N. Factors That Influence the Immune Response to Vaccination. Clin Microbiol Rev. 2019;32(2):e00084-18.
  6. Siegrist CA. The challenges of vaccine responses in early life: selected examples. J Comp Patho. 2007. l 137(Suppl 1):S4 –S9.
  7. Zimmermann P,(2) Curtis N. The influence of the intestinal microbiome on vaccine responses. Vaccine. 2018. 36:4433– 4439.
  8. Salk HM. Et al. Taxa of the nasal microbiome are associated with influenza-specific IgA response to live attenuated influenza vaccine. PLoS One 11:e0162803. 2016.
  9. Stephensen CB. Stool microbiota and vaccine responses of infants. Pediatrics. 2014. 134:e362– e372.
  10. Sadarangani SP, Whitaker JA, Poland GA. Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guérin vaccine revaccinated in Chinese infants. Expert Rev Vaccines. 2015; 14(11):1427-40
  11. Heine G. et al. Efficient tetanus toxoid immunization on vitamin D supplementation. Eur J Clin Nutr. 2011 65:329–334.
  12. Goncalves-Mendes N. et al. Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial. Front Immunol. 2019;10:65. Published 2019 Feb 8
  13. Patel N. et al. Baseline Serum Vitamin A and D Levels Determine Benefit of Oral Vitamin A&D Supplements to Humoral Immune Responses Following Pediatric Influenza Vaccination. Viruses. 2019;11(10):907.
  14. Zheng Y. et al. Enhancement of vitamin A combined vitamin D supplementation on immune response to bacille Calmette-Guerin vaccine revaccinated in Chinese infants. Asian Pac J Trop Med . 2014. 7:130 –135.
  15. Calder PC. Et al. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020;12(4):1181.
  16. Carr AC, Maggini S.  Zinc in Infection and Inflammation. Nutrients. 2017 Nov 3; 9(11)
  17. Gammoh NZ, Rink L.  Zinc and immunity: An essential interrelation. Nutrients. 2017 Jun 17; 9(6):
  18. Maares M, Haase H. Zinc and immunity: An essential interrelation. Arch Biochem Biophys. 2016 Dec 1;611:58-65.
  19. Colunga Biancatelli RML. Et al. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front Immunol. 2020;11:1451.
  20. Carr AC, Rowe S. The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19. Nutrients. 2020;12(11):3286.
  21. Davis JL. et al. Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury. Nutr Metab Insights. 2016;9:25-30.
  22. Dröge W, Breitkreutz R. Glutathione and immune function. Proc Nutr Soc. 2000 Nov;59(4):595-600.
  23. Fidelus RK. et al. Modulation of intracellular glutathione concentrations alters lymphocyte activation and proliferation. Exp Cell Res. 1987 Jun;170(2):269-75.
  24. Sinha R. et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition advance online publication, 30 August 2017.
  25. Guimarães LE. et al. Vaccines, adjuvants and autoimmunity. Pharmacol Res. 2015;100:190-209.
  26. Shoenfeld Y, N. Agmon-Levin, ‘ASIA’ – autoimmune/inflammatory syndrome induced by adjuvants, J. Autoimmun. 36 (2011) 4-8.
  27. Jara LJ. et al. Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld’s syndrome), Immunol. Res. 65 (2017) 8-16. 11.
  28. Baden LR. et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. The New England Journal of Medicine. 2020. DOI: 10.1056/NEJMoa2035389.
  29. Jensen G, Hamilton D. Transfer Factor selectively amplifies specific immune modulating properties of a colostrum herbal nutraceutical blend.  Unpublished research.
  30. Hamilton DE, Jensen GS. Pain reduction and improved vascular health associated with daily consumption of an anti-inflammatory dietary supplement blend. J Pain Res. 2019;12:1497-1508.

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