Radically Changing Your View of Water


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Nearly a decade later in 1974, again at Argonne National Labs, British scientist T.R. Griffiths, at the 2nd International Conference on Stable Isotopes, proposed the theory that deuterium might be the primary cause of aging. In Possible Roles of Deuterium in the Initiation and Propagation of Aging and Other Biochemical Mechanisms and Processes,4  he reported that deuterium, being twice as heavy, more electronegative and having different atomic binding properties than regular hydrogen, interfered with DNA replication. Because DNA repair enzymes contain deuterium in a position that is normally occupied by protium, they have a potential for triggering DNA replication and repair errors. The following year, in 1975, J.D. Gleason and I. Friedman, replicating the Russian findings on plant growth, published the first American study on using deuterium depleted water to increase the growth of grains. This small but significant publication in Nature5 magazine paved the way for a new generation of scientists to try and understand more deeply the function of deuterium in the biology of all living things.


Maintaining Health and Slowing Down Aging

When the Hunza people of northern Pakistan were investigated for their robust health and increased longevity, it was determined that the deuterium content of their water, from the glaciers of Mt. Ultar, was about 133 ppm, a deviation of 16% from the 155 ppm global reference for equatorial ocean water. A 16% reduction may not seem significant, however there are two factors that are in play. One is that the Hunza population is provided with this deuterium depleted water from birth to death and their vegetable, grain and fruit produce, as well as the animals they raise also are depleted in deuterium.  Two, Griffith had reason to postulate that the adverse biological effects of deuterium is “proportional to the square of the concentration.” This is the reason why researchers report that even a small depletion of deuterium has a significant biological benefit.

By the 1990s pivotal research was being furthered in Romania and Hungary. W. Bild and colleagues at the Romanian University of Medicine and Pharmacology showed that mice exposed to a sub-lethal dose of 8.5 grays of radiation had a greater survival rate on deuterium-depleted water. Mice consuming water that was reduced to 30 ppm of deuterium had a 61% survival rate whereas the control group consuming plain tap water (150 ppm) had a survival rate of only 25%. The test group also maintained normal white blood cell and red blood cell platelet counts as compared to the control group which did not. The same two groups of unfortunate rodents were also infected with pneumonia and the test group showed an intensification of immune defenses not seen in the control group. The scientists concluded that mice with lower levels of deuterium in their systems would benefit from fewer cell division errors and more effective repair of radiation-damaged DNA. It was proof yet again that deuterium-depleted water had some unknown and seemingly magical positive biological effect. Note: These animal tests were carried out for the sole purpose of evaluating the effects of deuterium depletion for patients undergoing chemotherapy.

The growing reported evidence from researchers, along with the work of Hungarian Nobel-prize winner Albert Szent-Györgyi, inspired the work of Gábor Somylai, a doctor and molecular biologist. In 1991 he engaged in the most extensive clinical trials of the physiological benefits of deuterium depletion ever conducted. His findings were published in 1998 in the paper “The Biological Effects of Deuterium Depletion”6 and his 2001 book Defeating Cancer.7 Somylai’s double-blind clinical trials first demonstrated that deuterium-depleted water was free of any side effects and, that the survivability of his test group on deuterium-depleted water was significantly better than those cancer patients in the control group. He also showed that consuming deuterium- depleted water was an excellent complementary adjuvant to conventional radiation and chemotherapy. Between October 1992 and the spring of 1999, Dr. Somylai and his team administered some 350,000 liters of deuterium-depleted water (DDW) to approximately 1,200 patients, generating over 12,000 pages of documented records. His groundbreaking work put Hungary on the map as an important center for research on the emerging health science of deuterium depletion.

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By the beginning of the 21st century, it was well understood among researchers that consumption of deuterium-depleted water (DDW) protected DNA from damage—but it was not understood how. It was only a matter of time until this mystery would be solved. In 2006, Russian chemist Igor A. Pomytkin and his colleague O.E. Kolesova published the study “Relationship between Natural Concentration of Heavy Water Isotopologues and Rate of H2O2 Generation by Mitochondria.”8 They were able to show that whatever cellular mechanism is susceptible to heavy water deuterium damage and, in turn, is protected by deuterium-depleted water (DDW) was located within the mitochondria. Scientists now understand that mitochondria have an inherent biological strategy for keeping cellular water free of deuterium—as the water inside the inner membranes of mitochondria has 60-70% less deuterium than extracellular water.


The Great Biological Discovery

The following year, 2007, marked the occasion of the most monumental discovery in the short history of deuterium science. Abdullah Olgun, PhD, a medical doctor, biochemist, and pharmacologist from the Department of Biochemistry and Clinical Biochemistry at Gülhane School of Medicine in Ankara, Turkey published the paper “Biological Effects of Deuteronation: ATP Synthase as an Example.”9 His pioneering research showed for the first time how deuterium caused its damage in Complex Five of the electron transport chain, inside the ATP Synthase nano-motor. Dr. Olgun determined that roughly every 15 seconds a bare heavier deuterium nuclei (a proton – neutron pair), impinges upon the fast spinning nano-motor, causing it to jam, stutter and ultimately self-destruct. Dr.Olgun further explained in his paper “Deuteronation and Aging,“10 published the same year in the Annals of the New York Academy of Science, that mitochondrial damage resulting from deuterium is one of the primary causes of physical aging. The mystery of how deuterium damaged life was finally revealed! The Nobel Prize worthy significance of Abdullah Olgun’s findings may be hailed as one of the greatest biological discoveries of the 21st century and the absence of recognition of his achievement stands as a careless oversight in the annuls of science.

At that time of Dr. Olgun’s groundbreaking discovery, few scientists realized the gravity of his breakthrough. One notable person that did was Anton Chernopiatko, a Russian businessman, scientist and deuterium depletion enthusiast who also co-authored with Pomytkin the 2015 study “Deuterium Content of Water Increases Depression Susceptibility: The Potential Role of a Serotonin-Related Mechanism.”11Having embraced the importance of deuterium-depletion from an early age, a lifelong quest was ultimately put into action. Chernopiatko, now having definitive proof of the role of deuterium as a biological Trojan horse, took it upon himself to advance deuterium-depleted water production technology beyond laboratory and research purposes and construct a factory to produce it on a commercial scale.  

Whereas Berdyshev in the 1990s had created an industrial process for reducing deuterium by 30-40% using a refrigerated process, it was around 2003 that the first vacuum-assisted fractional-distillation rectification column, exclusively for the production of deuterium-depleted water, was developed at the Institute of Fine Chemical Technologies in Moscow. This efficient process could remove 95% or more of the heavy water deuterium. In 2012, Chernopiatko began construction of a plant in the Russian countryside commercializing the technology developed at the Institute in Moscow. Five years of advanced engineering, trial and error, and good old elbow grease yielded the first dedicated facility in the world to continuously produce 90%+ deuterium-depleted water (DDW).

It is 2020; the mechanisms of deuterium and how to remove it are well understood. Nevertheless, the awareness of this colossal discovery is still in its infancy. Four international conferences on deuterium depletion in Budapest have provided a place for scientists to present their work. One scientist keen on advancing the work is Laszlo Boros, MD, and professor at UCLA who is leading the charge in the new field of deutenomics. The objective of this new science is to understand how deuterium is managed by biological systems. According to Dr. Boros, “The structured water pool of the (cellular) cytoplasm can thus be considered as a ‘deuterium scavenging water tank’ that absorbs deuterium from carbohydrates and amino acids in order to protect mitochondrial ATPase nanomotors from breaking, among other functions!”12


The New Age of Deuterium Depletion

As of this writing, there are three primary producers of deuterium-depleted water, Preventa in Hungary, Qlarivia in Romania, and Vividi in Russia, which is offered in the United States by Litewater Scientific under their “Litewater” brand. This exclusive deuterium-depleted water (DDW) is notable for its 94-97% reduction of deuterium—the lowest in the world. Only time will tell how this new scientific revelation of deupletion (deuterium depletion) will impact health and longevity of mankind. So far, the science and its application to health and medicine show much promise.


References

  1. Toroptsev L, et. Al. Biological Role of Heavy Water in Living Organisms, Questions of Radiobiology and Hematology, publishing house of Tomsk University, 1966.                                                                                                
  2. Essen C. Biological Effects of Deuterium. Yale Journal of Biology and Medicine. 1964 Aug; 37(1): 99
  3. Katz J, Crespi H. Deuterated Organisms Cultivation and Uses. Science. March 11, 1966:151 (3715): 1187-1194.
  4. Griffiths TR. Possible Roles of Deuterium in the Initiation and Propagation of Aging and Other Biochemical Mechanisms and Processes. Proceedings of the second international conference on stable isotopes, Argonne National Lab., Ill. (USA); p. 3-18; 1975
  5. Gleason J, Friedman I. Oats may grow better in water depleted in oxygen 18 and deuterium. Nature. 1975; 256: 305.
  6. Somylai G. The Biological Effects of Deuterium Depletion, a possible new tool in cancer therapy, Zeitschrift fur Onkologie. January 1998.
  7. Somylai G. Defeating Cancer. 2002.  ISBN-13: 978-0759692619
  8. Pomytkin I, Kolesova O. Relationship between Natural Concentration of Heavy Water Isotopologues and Rate of H2O2 Generation by Mitochondria. Bulletin of Experimental Biology and Medicine. December 2006; 142(5):570-2
  9. Olgun A. Biological Effects of Deuteronation: ATP Synthase as an Example. Theoretical Biology and Medical Modeling.  2007; 4: 9.
  10. Olgun A, et al. Deuteronation and Aging. Annals of the New York Academy of Sciences. April 18, 2007.
  11. Strekalova T, et al, Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism. Behavioural Brain Research. January 15, 2015;277, 237-244
  12. Boros L, et al. Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Med. Hypotheses. 2016; 87: 69–74

BIO

Victor Sagalovsky is the co-founder of Litewater Scientific. He is an author, scientist, and teacher. Currently, Victor has directed his efforts to advancing the health, anti-aging, and longevity benefits of deuterium depletion and the production and distribution of Litewater DDW.

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