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Interestingly, more people with weak immune systems survived the Spanish flu than those with strong immune systems. This oddity may be attributed to the fact that a strong immune system generates excessive peroxynitrite and other cytokine inflammatory mediators and tremendous O/N stress, which results in extreme edema. In effect, healthy people were drowning in their own lung fluid. Cartoonist and Pogo creator Walt Kelly said it best, “We have met the enemy, and he is us.”

Many of these single-stranded positive RNA viruses infect humans such as the cold virus, SARS coronavirus (2002), MERS-CoV coronavirus (2012), Marburg virus, dengue virus, rotavirus, HIV virus, and most recently, the SARS–CoV2 coronavirusresponsible for the COVID-19 pandemic.

When vaccines are used against these viruses, their success is limited because of the constant genetic recombinations of the viruses. Yet, these viruses can often be inhibited during the early stage of infection if treatment with anti-inflammatory steroids occurs during the acute stage of inflammation.

Combining steroidal anti-inflammatory drugs with multiple antioxidant substances offers more therapeutic value because the combination inhibits the inflammatory system necessary for these viruses to replicate. My patented combination of antioxidants and steroids has been shown to be an effective cure for feline immunodeficiency virus (FIV) and feline leukemia virus and greatly inhibit HIV in humans.

The H1NI virus and its genetic variations are also susceptible to similar supplement and anti-inflammatory drug combinations. These retroviruses are dependent on the transcription factor nf-kappa B, which is greatly inhibited by steroidal anti-inflammatory drugs such as methylprednisolone acetate (Depo-Medrol^®), dexamethasone, prednisone, and prednisolone.

Tetrandrine, a bisbenzyisoquinoline alkaloid, has anti-inflammatory actions that inhibit the infection of Ebola virus. A small dose of this calcium channel-blocking compound would be protective particularly with the use of steroids and antioxidants as proposed above. Tetrandrine can help prevent DHB, CBD and other supplements from being pumped out of cells to help maintain correct intracellular concentrations. This helps prevent drug exit and produces primary drug or primary supplement potentiation.

Sustained-release vitamin C, N-acetyl cysteine and other sustained-release antioxidants are particularly effective. Phenolic supplements such as sustained-release DHB, which metabolize to mono-, di- and polyphenols, and sustained-release CBD are also beneficial because they act as targets and neutralize the peroxynitrite radical, the main controller of chronic inflammatory diseases. By targeting the underlying chronic inflammation caused by these deadly lung-acting viruses, these therapies provide a more complete and effective treatment regime. See Table 1 for a suggested prophylactic regime to reduce the risk for or progression of infection by one of these viruses.

Presently, a group in Germany is developing adjuvants that could increase immunity to the SARS-CoV coronavirus. This approach, which stimulates an immune response, is likely the wrong thing to do, based on the 1918 Spanish flu experience in which people with stronger immune systems were more likely to die. I believe this approach will wind up killing people needlessly because of what happened with H1N1 infection in 1918. The people with strong immune systems died quickly, while those with weak immune systems survived. It is a cautionary tale that portends that those who do not learn from history are likely to repeat it.

Separately, the present drug combinations proposed to treat COVID-19 fail to adequately treat older people with multiple chronic diseases or comorbidities. The use of sustained-release DHB if given early in the disease state will likely help. For example, the antimalarial drug chloroquine had been approved for treatment with COVID 19 patients. Using sustained-release DHB in conjunction with this drug may help improve drug efficacy. Moreover, using sustained-release DHB with an antimalarial drug would treat comorbidities like hypertension, type 2 diabetes, heart diseases, lung diseases, and cancer. Substantial evidence exists in the literature and complete reviews are available on request. 

O/N Stress and Cancer

Chronically activated macrophages and neutrophils underlie all chronic diseases. As described above, the resulting O/N stress can damage many types of cells, including the master molecule DNA. It’s a chronic inflammatory system gone astray that can lead to DNA mutation, irreparable cell damage, and ultimately cancer. This happens because chronic inflammatory diseases are caused by excessive peroxynitrite or its bicarbonate. Indeed, chronic inflammation is estimated to cause or stimulate one out of five cancers. Perhaps administering sustained-release DHB in combination with various anti-cancer drugs could provide synergistic benefits such that a lower drug dosage provides efficacy with less toxic side effects.

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