The Potential Role of the Mitochondria and Nicotinamide Riboside in Addressing COVID-19

References

Subscribe button
  1. Malavolta M, et al. Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats. Cells. 2020;9(4):909.
  2. Riley JS, Tait SW. Mitochondrial DNA in inflammation and immunity.EMBO Rep. 2020 Apr 3;21(4):e49799.
  3. White MJ, et al. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.Cell. 2014 Dec 18;159(7):1549-62.
  4. West AP, et al. Mitochondrial DNA stress primes the antiviral innate immune response.Nature. 2015 Apr 23;520(7548):553-7.
  5. Schoggins JW, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2014 Jan 30;505(7485):691-5.
  6. Sun B, et al.  Dengue virus activates cGAS through the release of mitochondrial DNA.Sci Rep. 2017 Jun 15;7(1):3594.
  7. Aguirre S, et al. Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection. Nat Microbiol. 2017 Mar 27;2:17037.
  8. Yoshizumi T, et al. Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. Nat Commun. 2014 Aug 20;5:4713.
  9. Tiku V, Tan MW, Dikic I. Mitochondrial Functions in Infection and Immunity. Trends Cell Biol. 2020 Apr;30(4):263-75.
  10. Shi CS, et al. SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome. J Immunol. 2014 Sep 15;193(6):3080-9.
  11. Fields JA, et al. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.Neurobiol Dis. 2016 Feb;86:154-69.
  12. Datan E, et al. Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation. Cell Death Dis. 2016 Mar 3;7:e2127.
  13. Liang Q, et al. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy.Cell Stem Cell. 2016 Nov 3;19(5):663-71.
  14. Joubert PE, et al. Chikungunya virus-induced autophagy delays caspase-dependent cell death. J Exp Med. 2012 May 7;209(5):1029-47.
  15. Liu F, et al. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol. 2011;13:254-62.
  16. Yoshikawa T, et al. Severe Acute Respiratory Syndrome (SARS) Coronavirus-Induced Lung Epithelial Cytokines Exacerbate SARS Pathogenesis by Modulating Intrinsic Functions of Monocyte-Derived Macrophages and Dendritic Cells. J Virol. 2009;3039-48.
  17. Lightowlers RN, Chrzanowska-Lightowlers ZMA. Salvaging Hope: Is Increasing NAD(+) a Key to Treating Mitochondrial Myopathy? EMBO Mol Med. 2014 Jun;6(6):705-7.
  18. Wang X, et al. Sirtuins and Immuno-Metabolism of Sepsis. Int J Mol Sci. 2018 Sep;19(9):2738.
  19. Minhas PS, et al. Macrophage De Novo NAD + Synthesis Specifies Immune Function in Aging and Inflammation. Nat Immunol. 2019 Jan;20(1):50-63.
  20. Weinberg SE, Sena LA, Chandel NS. Mitochondria in the Regulation of Innate and Adaptive Immunity. Immunity. 2015 Mar;42(3):406-17.
  21. Heer CD, et al. Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. https://www.biorxiv.org/content/10.1101/2020.04.17.047480v2.full  Accessed April 24, 2020.
  22. Yoshino J, Baur JA, Imai SI. NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27(3):513-28.
  23. Airhart SE, et al. An Open-Label, Non-Randomized Study of the Pharmacokinetics of the Nutritional Supplement Nicotinamide Riboside (NR) and Its Effects on Blood NAD+ Levels in Healthy Volunteers. PLoS One. 2017 Dec 6;12(12):e0186459.
  24. Dellinger RW, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct;7:12948.
  25. Khan NA, et al. Effective Treatment of Mitochondrial Myopathy by Nicotinamide Riboside, a Vitamin B3. EMBO Mol Med. 2014 Jun;6(6):721-31.
  26. Clerkin KJ, et al. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease.Circulation. 2020 Mar 21. [Epub ahead of print.]
  27. Otto MA.Cardiac symptoms can be first sign of COVID-19. The Hospitalist. March 26, 2020.
  28. Martens CR, Denman BA, Mazzo MR, et al. Chronic Nicotinamide Riboside Supplementation Is Well-Tolerated and Elevates NAD + in Healthy Middle-Aged and Older Adults.Nat Commun. 2018 Mar 29;9(1):1286.
  29. Diguet N, Trammell SAJ, Tannous C, et al. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy. Circulation. 2018 May 22;137(21):2256-73.
  30. Trammell SA, et al. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.Sci Rep. 2016 May 27;6:26933.
  31. Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 2019 Jul 5;9(1):9772.
Pages: 1 2 3