Page 1, 2, 3
1. Hayes JD, Dinkova-Kostova AT. The Nrf2 regulatory network provides and interface between redox and intermediary metabolism. Trends Biochem Sci. 2014; 39:199–218.
2. Kumar H, Kim I-S, et al. Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic disease. Nat Prod Rep. 2014; 31:109–139.
3. Baird L, Dinkova-Kostova AT. The cytoprotective role of the Keap1-Nrf2 pathway. Arch Toxicol. 2011;85:241–272.
4. Gao B, Doan A, Hybertson BM. 2014 The clinical potential of Nrf2 signaling in degenerative and immunological disorders. Clin Pharmacol. 6:19–34.
5. Sandberg M, Patil J, et al. 2014 NRF2-regulation in brain health and disease: Implication of cerebral inflammation. Neuropharmacology. 79:298–306.
6. Buelna-Chontal M, Zazueta C. 2013 Redox activation of Nrf2 and NF-kB: a double end sword? Cell Signal. 25:2548–2557.
7. Saito H. Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases. Biochem Pharmacol. 2013;85:865–872.
8. Seo H-A, Lee I-K. The role of Nrf2: adipocyte differentiation, obesity, and insulin resistance. Oxid Med Cell Longev. 2013;2013.
9. Mann GE, Niehueser-Saran J, et al. Nrf2-ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Acta Physiologica Sinica 2007;59:117–127.
10. Bocci V, Zanardi I. An integrated medical treatment for type-2 diabetes. Diabetes Metab Syndr. 2014;8:57–61.
11. Arnold P, Mojumder D, et al. 2014 Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways. Clin Pharmacol. 2014; 6:35–42.
12. Lee DH, Gold R, Linker RA. Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci.2012;13:11783–11803.
13. Zhuang C, Miao Z, Sheng C, Zhang W. Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review. Curr Med Chem. Epub 2014 Feb 16.
14. Lee JW, Bae CJ, et al. 3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo. Mol Cell Biochem. 2014;390:143–153.
15. Pedruzzi LM, Stockler-Pinto MB, et al. Nrf2-keap1 system versus NF-kB: the good and the evil in chronic kidney disease? Biochimie. 2012;94:2461–2466.
16. Kim J, Cha YN, Surh YJ. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res. 2010;690:12–23.
17. Wang W, Wu Y, et al. Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure. Brain Res. 2014;1544:54–61.
18. Mazzuferi M, Kumar G, et al. Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy. Ann Neurol. 2013;74:560–568.
19. Loboda A, Rojczyk-Golebiewska E, et al. Targeting Nrf2-mediated gene transcription by triterpenoids and their derivatives. Biomol Ther (Seoul). 2012;20:499–505.
20. Vomhof-Dekrey EE, Picklo MJ Sr. The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. J Nutr Biochem. 2012;23:1201–1206.
21. Cho HY, Kleeberger SR. Nrf2 protects against airways disorders. Toxicol Appl Pharmacol. 2010;244:43–56.
22. Reuland DJ, McCord JM, Hamilton KL. The role of Nrf2 in the attenuation of cardiovascular disease. Exerc Sport Sci Rev. 2013;41:162–168.
23. CY, Cheng YT, Chau CF, Yen GC. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway. J Agric Food Chem. 2012;60:100–107.
24. Colín-González AL, Santana RA, et al. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection. Oxid Med Cell Longev. 2012:907162. doi:10.1155/2012/907162. Epub 2012 May 17.
25. Yang CM1, Huang SM, et al. Apo-8'-lycopenal induces expression of HO-1 and NQO-1 via the ERK/p38-Nrf2-ARE pathway in human HepG2 cells. J Agric Food Chem. 2012;60:1576–1585.
26. Linnewiel K, Ernst H, et al. Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. Free Radic Biol Med. 2009;47:659–667.
27. Zhang M1, Wang S, et al. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. J Neurosci. 2014;34:1903–1915.
28. Nakagawa F, Morino K, et al. 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs. Biochem Biophys Res Commun. 2014;443:991–996.
29. Hsieh TC, Elangovan S, Wu JM. Differential suppression of proliferation in MCF-7 and MDA-MB-231 breast cancer cells exposed to alpha-, gamma- and delta-tocotrienols is accompanied by altered expression of oxidative stress modulatory enzymes. Anticancer Res. 2010;30:4169–4176.
30. Smolarek AK, So JY, et al. Dietary tocopherols inhibit cell proliferation, regulate expression of ERa, PPARg, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog. 2013;52:514–525.
31. Maher J, Yamamoto M. The rise of antioxidant signaling – the evolution and hormetic actions of Nrf2. Toxicol Appl Pharmacol. 2010;244:4–15.
32. Thimmulappa RK1, Mai KH, et al. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002;62:5196–5203.
33. Kwak MK, Wakabayashi N, et al. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem. 2003;278:8135–8145.
34. McMahon M, Itoh K, et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 2001;61:3299–3307.
35. Cho HY, Jedlicka AE, et al. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol. 2002;26:175–182.
36. Itoh K, Tong K, Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med. 2004;36:1208–1213.
37. Nair S1, Xu C, et al. Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Pharm Res. 2006;23:2621–2637.
38. Wang H1, Khor TO, et al. Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid. Mol Pharm. 2010;7:2185–2193.
39. Gerhäuser C1, Klimo K, et al. Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity. Mol Nutr Food Res. 2009;53:1237–1244.
40. Willcox DC, Willcox BJ, et al. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr. 2009;28 Suppl:500S–516S.
41. Murakami A, Ishida H, et al. Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis. Asian Pac J Cancer Prev. 2005;6:437–448.
42. Suzuki M, Wilcox BJ, Wilcox CD. Implications from and for food cultures for cardiovascular disease: longevity. Asia Pac J Clin Nutr. 2001;10:165–171.
43. Kafatos A, Verhagen H, et al. Mediterranean diet of Crete: foods and nutrient content. J Am Diet Assoc. 2000;100:1487–1493.
44. Manios Y, Detopoulou V, et al. Mediterranean diet as a nutrition education and dietary guide: misconceptions and the neglected role of locally consumed foods and wild green plants. Forum Nutr. 2006;59:154–170.
45. Willett WC, Sacks F, et al. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl):1402S–1406S.
46. Simopoulos AP. The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. J Nutr. 2001;131(11 Suppl):3065S–3073S.
47. Salen P, de Lorgeril M. The Okinawan diet: a modern view of an ancestral healthy lifestyle. World Rev Nutr Diet. 2011;102:114–123.
48. Simopoulos AP. Omega-3 fatty acids and antioxidants in edible wild plants. Biol Res. 2004;37:263–277.
49. Lewis KN, Mele J, Hayes JD, Buffenstein R. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010;50:829–843.
50. Seymour EM, Bennink MR, Bolling SF. Diet-relevant phytochemical intake affects the cardiac AhR and Nrf2 transcriptome and reduces heart failure in hypertensive rats. J Nutr Biochem. 2013;24:1580–1586.
51. Schäfer M, Willrodt AH, et al. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014;6:442–457.
52. Tan NS, Wahli W. The emerging role of Nrf2 in dermatotoxicology. EMBO Mol Med. 2014;6:431–433.
53. Wakabayashi N, Itoh K, et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003;35:238–245.
54. Pall ML. Explaining "Unexplained Illness": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. New York: Harrington Park (Haworth) Press; 2007.
55. Pall ML. Teufelskreis NO/ONOO--Zyklus, oxidaver Stress, mitochondriale, inflammatorische und neurologische Dysfunktion. Umwelt Medizin Gesellshaft. 2010;23:281–293.
56. Pall ML. The NO/ONOO- cycle as the central cause of heart failure. Int J Mol Sci. 2013;14:22274–22330.
57. Pall ML. Is open-angle glaucoma caused by the NO/ONOO(-) cycle acting at two locations in the eye? Med Hypothesis Discov Innov Ophthalmol. 2014;4:1–2.
58. Pall ML, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Acta Physiologica Sinica. 2015;67:1–18.
Martin L. Pall, PhD, Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University
638 NE 41st Ave.
Portland, Oregon 97232-3312
Stephen Levine, PhD, founder and former CEO of the Allergy Research Group. firstname.lastname@example.org
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