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From the Townsend Letter
November 2015

Fibromyalgia
by Leslie Axelrod, ND, LAc
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Notes
1.   Wolfe F et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160–172.
2.   Wolfe F et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600–610.
3.   Korszun A. Sleep and circadian rhythm disorders in fibromyalgia. Curr Rheumatol Rep 2000:2(2):124–130.
4.   Wikner J et al. Fibromyalgia – a syndrome associated with decreased nocturnal melatonin secretion. Clin Endocrinol (Oxf). 1998;49(2):179–183.
5.   Crofford LJ et al. Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain Behav Immun. 2004;18(4):314–325.
6.   Hellhammer J et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress.2004 Jun;7(2):119–126.
7.   Citera G et al. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol. 2000;19(1):9–13.
8.   Maroo N et al. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian J Pharmacol. 2013 Jan–Feb;45(1):34–39.
9.   Woelk H, Schläfke S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010 Feb;17(2):94–99.
10. Fißler M, Quante A. A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety. Complement Ther Med. 2014 Feb;22(1):63–69.
11. Rahimi R. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(1):118–127.
12. Caruso I et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990:18(3):201–209.
13. Sarzi P, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res. 1992;20(2):182–189.
14. Jacobsen S et al. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol. 1991;20(4):294–302.
15. Almansa C et al. Prevalence of functional gastrointestinal disorders in patients with fibromyalgia and the role of psychologic distress. Clin Gastroenterol Hepatol. 2009;7(4):438–445.
16. Caldarella MP et al. Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia. Am J Gastroenterol. 2006 Dec;101(12):2782–2789.
17. Crowell MD. Role of serotonin in the pathophysiology of the irritable bowel syndrome. Br J Pharmacol. 2004;141(8):1285–1293.
18. Zuo XL et al. Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy. 2007;7(6):823–830.
19. Zar S et al. Food-specific IgG4 antibody-guided exclusion diet improves symptoms and rectal compliance in irritable bowel syndrome. Scand J Gastroenterol. 2005;40(7):800–807.
20. Arroyave H. Food allergy mediated by IgG antibodies associated with migraine in adults. Rev Alerg Mex. 2007;54(5):162–168.
21. Goebel A et al. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Rheumatology (Oxford). 2008;47(8):1223–1227.
22. Pimentel M. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol. 2000;95(12):3503–3506.
23. Lauritano EC et al. Small intestinal bacterial overgrowth recurrence after antibiotic therapy. Am J Gastroenterol. 2008;103(8):2031–2205.
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25. Xu D. Elemental diet-induced bacterial translocation associated with systemic and intestinal immune suppression. J Parenter Enteral Nutr. 1998;22(1):37–41.
26. Bures J. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28;16(241):2978–2990.
27. Chedid V et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med. 2014 May;3(3):16–24.
28. Ankri S et al. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999;1(2):125–29.
29. Freile ML et al. Antimcrobial activity of aqueous extracts of berberine isolated from Berberis heterophylla. Fitoterapia. 2003;74(7–8):702–705.
30. Thompson A. Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome. BMC Complement Altern Med. 2013;28;13:338.
31. Mas AJ et al. Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population: results from a nationwide study in Spain. Clin Exp Rheumatol. 2008;26(4):519–526.
32. Almansa C. Prevalence of functional gastrointestinal disorders in patients with fibromyalgia and the role of psychologic distress. Clin Gastroenterol Hepatol. 2009;7(4):438–445.
33. Liu W et. al. Benefit of Qigong exercise in patients with fibromyalgia: a pilot study. Int J Neurosci.2012;122(11):657–664.
34. Sephton SE et al. Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: results of a randomized clinical trial. Arthritis Rheum. 2007;57(1):77–85.
35. Menzies V. Effects of guided imagery on outcomes of pain, functional status, and self-efficacy in persons diagnosed with fibromyalgia. J Altern Complement Med. 2006;12(1):23–30.
36. Gowans SE, deHueck A. Pool exercise for individuals with fibromyalgia. Curr Opin Rheumatol. 2007;9(2):168–173.
37. Bote ME et al. Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise. PLoS One. 2013;4;8(9).
38. Valim V et al. Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: a randomized pilot study. Rev Bras Reumatol. 2013;53(6):538–541.
39. Homann D et al. Impaired functional capacity and exacerbation of pain and exertion during the 6-minute walk test in women with fibromyalgia. Rev Bras Fisioter. 2011;15(6):474–480.
40. Jeschonneck M et al. Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia. Rheumatology (Oxford). 2000;39(8):917–921.
41. Mizuno K et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24(4):293–299.
42. Lister RE. An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int Med Res. 2002;30(2):195–199.
43. Abdullah M et al. Mitochondrial myopathy presenting as fibromyalgia: a case report. J Med Case Reports. 2012;6:55.
44. Rossini M et al. Double-blind, multicenter trial comparing acetyl L-carnitine with placebo in the treatment of fibromyalgia patients. Clin Exper Rheumatol. 2007;25(2):182–188.
45. Gerdle B. Increased interstitial concentrations of pyruvate and lactate in the trapezius muscle of patients with fibromyalgia: a microdialysis study. Rehabil Med. 2010 Jul;42(7):679–687.
46. Kiyak EK. A new nonpharmacological method in fibromyalgia: the use of wool. J Altern Complement Med. April 2009, 15(4):399–405.
47. Sprott H et al. Microcirculatory changes over the tender points in fibromyalgia patients after acupuncture therapy (measured with laser-Doppler flowmetry). [In German.]Wien Klin Wochenschr 2000;112(13):580–586.

Dr. Leslie AxelrodDr. Leslie Axelrod has been a naturopathic physician since 1987, when she graduated from Bastyr University. She is a professor of clinical sciences at the Southwest College of Naturopathic Medicine. She is also a nationally certified and state licensed acupuncturist. Dr. Axelrod has been in private practice in an integrative rheumatology practice for the past 16 years. She is a published author on the topic of fibromyalgia in the Australian text Clinical Naturopathy: An Evidence-based Guide to Practice (Elsevier 2010, 2nd ed. 2014) and coauthor of "Efficacy of Methylsulfonylmethane (MSM) in Osteoarthritis Pain of the Knee: A Pilot Clinical Trial" (Osteoarthritis Cartilage. 2006 Mar;14(3):286–294). She has written articles on autoimmunity in Naturopathic Doctor News & Review (NDNR).

 

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