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1, 2, Notes
CHICKENPOX
VACCINE
Another example of changes to the US vaccination
protocol was the addition in 2006 of a second dose of varicella (chickenpox)
vaccine
to the childhood
immunization schedule. This dose is recommended for universal vaccination
of all children at ages four to six and for any child, adolescent
or adult who
previously has received only one dose. The first dose of the varicella
vaccine was recommended for children in 1995.76
The ACIP recommended the second dose at four to six years of age "to
further improve protection against the disease."77 The fact is, outbreaks
of varicella have occurred despite increasing coverage with the first dose
of the vaccine. In a survey of 59 jurisdictions (states, large cities,
and US territories) by the CDC, 45 jurisdictions were notified of at least
once
varicella outbreak in 2004, and 13 were notified of six or more. Data obtained
on 190 outbreaks in 2004 showed that two-thirds occurred in elementary
schools.78
Varicella outbreaks may occur even in highly vaccinated communities,
and vaccinated children are still at risk of contracting the disease.79-81 According
to the CDC, 11% to 17% of vaccinated children have developed chickenpox—so-called "breakthrough
varicella"—in recent outbreaks of the disease among vaccinated
schoolchildren.82 In three studies, rates of infection
in vaccinated individuals ranged from 18% to 34% anywhere from five
to ten years following immunization.83-85
In other recent studies of chickenpox outbreaks, vaccine effectiveness
against varicella of any severity ranged from 44% to 87%. Effectiveness
was as high
as 97% for moderate or severe illness.86-91 Research
also shows that people with breakthrough varicella tend to have milder
illness
than do unvaccinated people who contract the disease,92 although
the vaccinated individuals can be just as infectious.93
VAERS received 6,574 reports of adverse events for the varicalla
vaccine from March 17, 1995 to July 25, 1998. Approximately four
percent of
reports concerned
serious events (such as anaphylaxis, thrombocytopenia, pneumonia,
and convulsions) and deaths.94
The dangers of adult chickenpox. In most cases chickenpox is a benign,
self-limiting disease in children, and the natural immunity derived
from contracting the
disease is permanent. Vaccine-induced immunity, on the other hand,
lasts only an estimated six to ten years. The temporary nature of
vaccine-induced immunity
can create a more dangerous situation by postponing the child's vulnerability
until adulthood, when death from the disease is 30 times more likely.
The National Vaccine Information Center (NVIC), Vienna, Va., advises
parents to seriously consider not using the chickenpox vaccine in
healthy children.
According to Barbara Loe Fisher, cofounder and president, "The case/fatality
ratio in healthy children is one death per 100,000 children. In adults, it
rises to 31 deaths per 100,000. So it basically is an experiment. That is really
what happens with most of these vaccines that they bring out. They really don't
know what the long-term effect is going to be." Dr. Link, however, cautions
that if most children are immunized according to the current US policy of universal
vaccination, "it may be unwise to try to avoid vaccination because of
the hazard of later acquiring varicella as an adult."95
The temporary immunity provided by the vaccine is a particular concern
for pregnant women. Normally, 90% of adult women are immune to varicella
and
transfer this immunity to their babies during pregnancy. But the
immunity induced by
vaccination, which lasts only five to ten years, may be gone by the
time a woman enters her reproductive stage, leaving pregnant women
at risk
of contracting
the infection and transmitting it to the fetus. Fetal varicella syndrome
is characterized by multiple congenital malformations and is often
fatal for the
fetus.96 In addition, children born to women whose vaccine-induced
immunity has faded are unprotected during the first year of life,
when their immune
system is still developing, and may suffer fatal complications if
exposed to the infection.
Another potential problem in the coming years is an increase in the
rate of shingles due to widespread use of the varicella vaccine.
As Dr. Link
explains, the varicella zoster virus causes both chickenpox and herpes
zoster (shingles).
The virus could lie dormant for many years and later become active
and cause shingles due to a reduction in immunity. One report states
that
mass vaccination
with varicella "is expected to cause a major epidemic of herpes zoster."97
And while some research has not found in increase in the rate of shingles,
reports Dr. Link, it will be years before we know whether the vaccine virus
is too weak to be activated or the immunity produced by the vaccine is
too weak to control the virus.98
It is of interest that the FDA approved the first vaccine for herpes
zoster in 2006. Zostavax is a live vaccine licensed for use in people
age 60 and
older. In a study of approximately 38,000 people, the vaccine reduced
the incidence
of herpes zoster by about 50% overall. Effectiveness ranged from
64% for people age 60-69 to 18% for those 80 and older.99
HEPATITIS
B VACCINE
The hepatitis B vaccine became commercially
available in the US in 1982 and was recommended for certain high-risk
groups
of people.
However, when vaccination programs aimed at these groups did
not stem an increase in hepatitis B infections, the ACIP recommended
universal immunization of infants against this disease in 1991.100
An analysis of reports made to VAERS over 11 years—from 1991 to 2001—found
that hepatitis B was the most frequently mentioned vaccine in 1991-1995 reports
and the second-most commonly mentioned (after varicella) in 1996-2001 reports.101
An earlier study found that 12,520 adverse reactions to hepatitis B were
reported to VAERS from 1991 to 1994, with 14% of these reactions involving
newborns
and infants.102 Approximately one-third of reactions involved an emergency
room visit or hospitalization, according to the Association of American
Physicians and Surgeons (AAPS). There were 440 deaths, about 180 of which
were attributed
to SIDS.103
Dr. Jane M. Orient, executive director of AAPS, has stated that according
to a federal government study, "Children younger than 14 are three times
more likely to die or suffer adverse reactions after receiving hepatitis B
vaccines than to catch the disease."104
In adults, hepatitis B vaccination was associated with serious autoimmune
disorders in one analysis of VAERS data and a review of the literature,
published in
2004. These disorders included arthritis, pancytopenia/ thrombocytopenia,
multiple sclerosis, rheumatoid arthritis, myelitis, Guillain-Barre syndrome,
and optic
neuritis. In adult use of the hepatitis B vaccine, there were 465 positive
re-challenge adverse events.105
Other articles associate the hepatitis B vaccine with complications of
the nervous system106-110 and joints111-116 and
other adverse effects.117 The Institute of Medicine stated in 2002 that "the
epidemiological evidence favors rejection of a causal relationship between
the hepatitis B vaccine in adults and multiple sclerosis." (The evidence
was inadequate to accept or reject a causal association with other demyelinating
conditions.)118 A case-control study published by the CDC in 2003 also
found that the hepatitis B vaccine is not associated with an increased
risk of multiple
sclerosis or optic neuritis.119 However, a case-control study
published in 2004 concluded that its findings "are consistent with
the hypothesis that immunization with the recombinant hepatitis B vaccine
is associated with
an increased risk of MS, and challenge the idea that the relation between
hepatitis B vaccination and risk of MS is well understood."120
The purpose of vaccinations is to reduce the risks of complications associated
with the diseases they are designed to prevent. Complications from a vaccine
should not outweigh those derived from the disease. And yet, according
to Dr. Philip Incao, who has studied vaccinations and the immune system
for
three
decades, in the case of hepatitis B, "...the conclusion is obvious that
the risks of hepatitis B vaccination far outweigh its benefits."121
Are vaccine-induced antibodies only temporary? Vaccine supporters claim
that the development of an antibody response to a vaccine virus equals
protection
against the disease. So we now vaccinate children against hepatitis B to
prevent them from contracting the disease later in life. But for this to
occur, the
level of antibodies that are supposed to be protective must remain high
for very long periods of time.
A study published in 2004 reports that antibodies to hepatitis B surface
antigen (anti-HBs) had disappeared by five years of age in most of the
low-risk children
studied who were vaccinated from birth against hepatitis B.122 A study
in the Gambia found that fewer than half of vaccinees had detectable anti-HBs
15 years
after vaccination and that vaccine efficacy against infection among 20-
to
24-year-olds was 70.9%. A positive finding was that hepatitis B vaccination
in early life can provide long-lasting protection against carriage of the
hepatitis B virus—a major risk factor for liver cirrhosis and hepatocellular carcinoma—despite
decreasing levels of anti-HBs.123
One study of adult hepatitis B vaccination evaluated the persistence of
anti-hepatitis-B antibodies in 635 homosexual men immunized against the
virus. After five
years, antibodies no longer existed in 15% and had declined sharply—below levels
deemed to be protective—in another 27%. Hepatitis B developed in 55
men, and two became carriers of the virus.124 Another study found that after
three
years, 36% of individuals who initially responded to the hepatitis B immunization
lost anti-hepatitis-B antibodies.125
Why then are we needlessly vaccinating millions of children if by the time
they'll be adults and might be exposed to the virus, they won't
have the antibodies that are supposed to protect them? And, in any case,
are these antibodies offering protection against the disease?
MEASLES, MUMPS,
AND RUBELLA (MMR) VACCINE
In recent years, two of three diseases targeted
by the MMR vaccine—measles
and rubella—have been virtually eliminated in the United States.
The last major resurgence of measles occurred in 1989-1991, when more
than 55,000
cases and approximately 120 deaths were reported. The ACIP recommended
in 1989 that a second dose of measles-containing vaccine be added to
the childhood
vaccination schedule, and the incidence of measles began to fall in 1992.
A
record low of 37 cases were reported in 2004.126,127 In 2000, a panel
of experts convened by the CDC determined that measles was no longer
endemic
in the US.128
Similarly, the incidence of rubella fell to nine cases in 2004, and it
was determined that rubella is no longer endemic in the US.129
Despite this success, concerns remain about adverse effects of MMR
vaccination. The Institute of Medicine has found evidence that this
vaccine can cause
anaphylaxis, thrombocytopenia, and acute arthritis.130,131 Other
research has associated
the vaccine with adverse effects on the nervous system132-137 gastrointestinal
tract,138 and joints.139-141
Meryl Dorey, editor of the Australian publication Vaccination?
The Choice is Yours and president of the Australian Vaccination Network,
points
out that
the MMR vaccine is associated with Guillain-Barre paralysis, multiple
sclerosis, and aseptic meningitis, a swelling of the lining of the
brain that can
be fatal. The CDC has noted that while cases of Guillain-Barre syndrome
following
MMR
vaccination have been reported, the IOM has found the evidence "insufficient
to accept or reject a causal relationship."142 Measles Vaccine
Vaccine failures. A study
published in 1994 evaluated all US and Canadian articles reporting
measles outbreaks in schools and
found that, on
average, 77 % of these infections occurred in vaccinated people.
The authors concluded, "The apparent paradox is that as measles
immunization rates rise to high levels in a population, measles becomes
a disease of immunized persons."143 The New England Journal
of Medicine has reported that 60%
of all measles cases among American schoolchildren between 1985 and
1986 occurred in those who were vaccinated.144 Other studies
confirm a high percentage of measles among vaccinated subjects.145,146
Vulnerabilities related to the measles vaccine. Natural
immunity to measles—derived from contracting the disease—is
permanent and is transferred from mothers to babies in utero through
the placenta.
Babies born to mothers who have had the disease are protected from
the infection during their first year of life by the presence of
a high concentration of natural antibodies circulating in their
blood.
Measles vaccination, on the other hand, induces lower antibody titers
than does natural infection. Neutralizing measles antibodies passed
by vaccinated women to their newborns disappear rapidly, leaving
the babies susceptible to the infection in their first year of
life, when
they are more at risk of complications.
This difference in infants' immunity levels is reflected in a
1995 study. Researchers found that 71% of nine-month-olds and 95% of
12-month-olds had no detectable neutralizing measles antibodies in
their blood. All infants with detectable measles antibodies at nine
or 12 months had mothers born before 1963, before the vaccine era.147
Research confirms that antibody response to the vaccine virus is only
temporary. One study shows that four years after MMR vaccination, measles
antibodies fell below the putative protective levels in 28% of children
and were no longer present in another three percent of vaccinees.148 Experimenting
with high-potency vaccines produced even poorer results.149
Jamie Murphy, author of What Every Parent Should Know About
Childhood Immunization, argues that
rather than preventing measles, the vaccine may simply suppress it,
only to have it manifest as other forms of
disease with age.150 He asserts that quite a few diseases are associated
with the measles vaccine, including "encephalopathies (brain
damage), aseptic meningitis, cranial nerve palsy, learning disabilities,
hyperkinesis, and severe mental retardation...."151 Several studies
have documented that measles vaccination produces immune suppression
that contributes to an increased susceptibility to other infections.152,153 One study links measles vaccination to Crohn's disease.154
Problems with vaccine testing. In
a response to information provided by the World Health Organization,
author and lecturer Trevor Gunn has
identified shortcomings in the testing of vaccines and the rationale
for mass immunization, particularly with regards to measles.155 One
problem is that vaccine studies use seroconversion, or antibody presence
in the bloodstream, to indicate effectiveness. When UK health authorities
say that the measles vaccine is 90% effective, they do not mean that
it reduces the incidence, severity, or death rate of the disease
by 90%, but rather that 90% of recipients produce a certain level
of antibodies
to the viral agents. However, the level of serum antibodies does
not correlate with the body's ability to fight illness. People with
low antibody levels may demonstrate immunity, while people with higher
antibody levels may have no immunity.
Given this disconnect, says Gunn, we must "place a greater reliance
on obtaining efficacy results of immunisation from population studies." These
studies measure the level of disease protection in populations after
they've been inoculated, using cohort groups matched for age,
population, and disease exposure similarities, and so forth. Although
WHO quoted references to a number of population studies in its communication
with Gunn, the author says that all of the studies were conducted in
developing countries. Thus, the results cannot be "directly extrapolate
to developed countries," where people may fear that the risks
of vaccination outweigh the risk of contracting a disease such as
measles.
In addition, notes Gunn, population studies referenced by WHO show
the difficulties of vaccine testing. One study, for example, suggests
that measles vaccination reduces childhood mortality by 30%. However,
the control group was not non-vaccinated, but rather included children
who did not seroconvert and thus were assumed to have no immune response
to the vaccine. In this case, we would not know whether deaths in
the control group were due directly to the vaccine, to its lack of
effectiveness,
or to lack of natural immunity provided by the measles itself. In
another group in this study, 15 of 123 did not have antibody conversion
after
vaccination, so their results were excluded as well. Three of this
group actually died. We do not know the cause of these deaths, or
whether the remaining 12 in the group were prevented from getting
the disease.156 In another study, the cohort group was
cherry-picked for people who did not have a history of measles. This
group may have been less likely
to die from measles in general or may be heartier in general than
the people who were selected against in the study.157
Mumps Vaccine
Although
mumps infection is a largely benign disease when contracted during
childhood, it becomes more dangerous in older children and adults,
who are more susceptible to severe neurological, testicular, and
ovarian
complications from the infection. It is alarming to see that vaccination
is clearly shifting the occurrence of this disease from young children
toward those who are older.158
A large outbreak of mumps occurred in the United States in 2006, with
5,783 cases being reported to the CDC in less than ten months (from
January 1 to October 7). The median age for the mumps patients was
22 years, and the highest age-specific rate was among people 18 to
24 years of age, many of them college students.159
Questions about efficacy. The
resurgence of mumps raises concerns about vaccine failure. Although
the CDC does not know the vaccination history
of all the 2006 cases, it has reported that 63% of 1,798 patients
in Iowa (which had the highest number of cases) had received one
or two
doses of the MMR vaccine.160
Other mumps outbreaks have occurred in highly vaccinated populations
in the US and Europe.161-163 The populations in several
of these studies had virtually complete vaccination coverage. In
a high school
population with more than 95% coverage, 53 of 54 students who got
the disease were vaccinated.164 In a Tennessee school
with 98% coverage, 67 of 68 students who got mumps were vaccinated.
Thus, mumps
cases
in this instance were attributed mostly to vaccine failure.165
Perhaps the boldest statement on the efficacy of the mumps vaccine
comes from the authors of an epidemiological study conducted in
Switzerland. They found a fivefold increase in the number of mumps
cases from 1990
to 1993, especially in vaccinated children. Among the authors'
conclusions was: "The Rubini [mumps] strain vaccines, which
are the most commonly used in Switzerland, seem to have played
an important role
in the clear increase in mumps cases since 1990."166
Urabe strain and meningitis. Another
strain of mumps virus used in vaccines has been associated with
the development of aseptic
meningitis.167 The Urabe strain is not used in vaccines
in the US, but it has been used in Canada and the United Kingdom
in the past. This strain of mumps
virus was identified as the cause of aseptic meningitis in 1989
in patients who developed meningitis 21 days after injection. The
virus
isolated from these patients was identical to that used in the
vaccine.
The Urabe strain of the mumps virus was removed from Canadian vaccines
in 1989168 because of a meningitis outbreak. The strain
was removed in the UK in 1992. According to Trevor Gunn, when laboratory
and hospital
reports were cross-linked to vaccination records there, "the
[perceived low risk of meningitis from this particular vaccine]
rose to between one in 4,000 and one in 21,000."169 Despite
these vaccine withdrawals, a mass immunization campaign targeting
children
one to 11 years old was carried out in 1997 in Salvador, Brazil,
with a Urabe-containing MMR vaccine. An outbreak of aseptic meningitis
followed,
with 58 cases diagnosed.170
Rubella Vaccine
A
study published in 1981 found that 15 years after receiving rubella
vaccination, one in 11 children lost protection and became susceptible
to re-infection.171 This is worrisome because rubella
infection is especially dangerous when contracted during pregnancy,
since the fetus
may develop malformations if exposed to the virus. Again, the
lack of permanent immunity offered by vaccinations is creating
serious problems
down the line.
Viera Scheibner, a retired research scientist, notes that in
a 1991 report on the adverse effects of pertussis and rubella
vaccines from
the Institute of Medicine, "the evidence indicated a causal
relationship between RA 27/3 rubella vaccine and acute arthritis
in 13% to 15% of
adult women. Also some individuals were shown to go on to develop
chronic arthritis."172
In
Part 3: Rotavirus, meningococcal, and smallpox vaccines; provocation
diseases associated with vaccination; economic and legal issues and
the right to refuse vaccination.
Page 1,
2, Notes
Gary Null, PhD
2307 Broadway
New York, New York 10024 USA
646-505-4660/ Fax 212-472-5139
e-mail: precisemd@aol.com Gary Null, PhD has authored more than
50 books on health and nutrition and numerous articles published
in research journals. He holds a PhD
in human nutrition and public health science from the Union Graduate
School. Dr. Null's website, www.garynull.com, presents information
on how to optimize health through nutrition, lifestyle factors and
alternative medicine.
Martin Feldman, MD practices complementary medicine. He is an Assistant
Clinical Professor of Neurology at the Mount Sinai School of Medicine
in New York City.
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