Gut Microbiome: Mood Micromanager? (Oct 2015) Townsend Letter, Alternative Medicine Magazine

From the Townsend Letter
October 2015

Order this issue!

The Gut Microbiome: Your Mood's Micromanager?
by Filomena Trindade, MD, MPH, and Megan Murphy, CAP

Page 1, 2, 3

References

Bercik P et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogasteroenterol Motil. 2011. December;23(12):1132–1139. doi:10.1111/j.1365-2982.2011.01796.x.

Bercik P et al. The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis. Adv Exp Med Biol. 2014;817:279–289. doi:10.1007/978-1-4939-0897-4_13.

Bercik P, Bolino CM. Pathogenic factors involved in the development of irritable bowel syndrome: focus on a microbial role. Infect Dis Clin North Am. 2010 Dec;24(4):961–975, ix. doi:10.1016/j.idc.2010.07.005. Review.

Berk M et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013 Sep 12;11:200. doi:10.1186/1741-7015-11-200.

Borre YE et al. The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol. 2014;817:373-403. doi:10.1007/978-1-4939-0897-4_17.

Bravo JA et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050–16055.

Dinan TG et al. Psychobiotics: a novel class of psychotropic. Biol Psychiatry. 2013 Nov 15;74(10):720–726. doi:10.1016/j.biopsych.2013.05.001.

Fichna J, Storr M. Brain-gut interactions in IBS. Frontiers in Pharmacology. July 2012 (3)127. doi:10.3389/fphar.2012.00127.

Fond G et al. The "psychomicrobiotic": Targeting microbiota in major psychiatric disorders: A systematic review. Pathol Biol (Paris). 2015 Feb;63(1):35–42. doi:10.1016/j.patbio.2014.10.003.

Hilimire MR, DeVylder JE, Forestell CA. Fermented foods, neuroticism, and social anxiety: an interaction model. Psychiatry Res. 2015 Aug 15;228(2):203–208. doi:10.1016/j.psychres.2015.04.023. Epub 2015 Apr 28.

Holzer P et al. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides. 2012 Dec;46(6): 261–274. doi:10.1016/j.npep.2012.08.005.

Jørgensen BP et al. A possible link between food and mood: dietary impact on gut microbiota and behavior in BALB/c mice. PLoS One. 2014 Aug 18;9(8):e103398. doi:10.1371/journal.pone.0103398.

Karakuła-Juchnowicz H et al. The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders. Nutr Neurosci. 2014 Sep 30

Labus JS et al. Irritable bowel syndrome in female patients is associated with alterations in structural brain networks. Pain. 2014 Jan;155(1):137–149. doi:10.1016/j.pain.2013.09.020.

Little A. Treatment resistant depression. Am Fam Physician. 2009 Jul 15;80(2):167–172.

Loftis J et al. Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies. Neurobiol Dis. 2010 March;37(3):519–533.

Mayer EA et al. Gut/brain axis and the microbiota. J Clin Invest. 2015 Mar 2;125(3):926–938. oi:10.1172/JCI76304.

Montiel-Castro AJ et al. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality. Front Integr Neurosci. 2013 Oct 7;7:70. doi:10.3389/fnint.2013.00070.

National Institute for Occupational Safety and Health. July 23, 2006.

Park AJ et al. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil. 2013 Sep;25(9):733–e575. doi:10.1111/nmo.12153.

Perlmutter D. Brain Maker. Little Brown and Company; 2015.

Tillisch K. The effects of gut microbiota on CNS function in humans. Gut Microbes. 2014 May–Jun;5(3):404–410. doi:10.4161/gmic.29232.

Qureshi NA, Al-Bedah AM. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. 2013;9:639–658. doi:10.2147/NDT.S43419.

Simões CD et al. Habitual dietary intake is associated with stool microbiota composition in monozygotic twins. J Nutr. 2013 Apr;143(4):417-23. doi:10.3945/jn.112.166322.

Söderholm JD, Perdue MA. Stress and the gastrointestinal tract II. Stress and intestinal barrier function. Am J Physical Gastrointest Liver Physiol. 2001;280:G7–G13.

US Department of Health and Human Services. Treatment of Depression After Unsatisfactory Response to SSRIs: Executive Summary. Effective Health Care Program. Comparative Effectiveness Review. April 26, 2012;62.

Zhou L, Foster J. Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatr Dis Treat. 2015 Mar 16;11:715–723. doi:10.2147/NDT.S61997.

Filomena Trindade, MD, MPH, is a teacher, author, and international sought-after speaker in functional medicine. She is a graduate of the fellowship in Anti-Aging, Regenerative and Functional Medicine and teaches in the Fellowship (a master's program through the University of South Florida). After obtaining her BA degree in biology she went on to finish a master's in public health in the area of environmental health and epidemiology before starting medical school. She graduated first in her class in family practice from the University of California Davis School of Medicine and did her residency training in family practice at the UC San Francisco/Santa Rosa Program. She has been in clinical practice for over 18 years. Before starting her own private practice in 2004 in functional medicine, she was the medical director of a large nonprofit organization that catered to the underserved. She is currently very active in developing teaching programs in functional medicine in the US, Latin America, and Europe.

Page 1, 2, 3

Consult your doctor before using any of the treatments found within this site.

Subscriptions are available for Townsend Letter, the Examiner of Alternative Medicine
magazine, which is published 10 times each year. Search our pre-2001 archives for further information. Older issues of the printed magazine are also indexed for your convenience.
1983-2001 indices ; recent indices. Once you find the magazines you'd like to order, please
use our convenient form, e-mail subscriptions@townsendletter.com, or call 360.385.6021.

360.385.6021
Fax: 360.385.0699
info@townsendletter.com