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From the Townsend Letter
October 2006


Recent Progress in Clinical Applications
and Research in Fibromyalgia

by Robert W. Bradford, Professor of Medicine, D. Sc. NMD, and Henry W. Allen, Director of Clinical Biochemistry, BRI

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The article. . . 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12


Table of Contents

Sleep Disturbances
Gender Difference
Psychological Impact
Skin Hypoxia
Environmental Chemical Sensitivity
Muscle Abnormalities
Altered Cerebral Blood Flow
Hormone Imbalance
Genetic Alterations

Nocturnal Melatonin Secretion
  Antibodies to Serotonin
Serotonin Level in Jaw Muscle
Bilayer Lipid Membrane
Nerve Cells

Pain Mechanism of Fibromyalgia
  Substance P
    Hydrogen Bond
Benzene Rings
Miscellaneous Responses from Substance P
  Bacteria Binding to Lymphocytes Inhibited
Increased CNS Invasion by HIV-1 from Substance P
Infectious Microorganisms in Fibromyalgia Patients

Rationale for Fibromyalgia/CFS Fatigue
  Cyclopiazonic Acid
Chemistry of Cyclopiazonic Acid and Gliotoxin

Mitochondrial Damage
Recently Discovered Fibromyalgia Symptoms
  Dry Eyes and Mouth
Environmental Chemical Sensitivity
Inflammatory Response System
Adrenal Insufficiency
Muscle Weakness
Latent HIV Activation
Inhibition of TNF-alpha Production by T-Cells
Fibrinolysis Inhibition
Muscle Cramps and Spasms
Edema, Cataracts and Psychological Responses/Depression
Comparison of Fibromyalgia/Fungemia Symptoms
  Cardio/Respiratory Insufficiency
Fungus in Diseases Other Than Fibromyalgia
  Fungus in Cancer
Fungus in Arthritis
Prostaglandin Production by Pathogenic Fungi
Pulmonary Aspergillosis in AIDS Patients
Mucor Cerebral Aneurysm
Clinical Outcome Study for Fibromyalgia
Adverse Reactions
Pre-Therapy Considerations (Figure 1)
Post-Therapy Considerations for FMS – 90 Days (Figure 2)

Clinical Outcome
Detection of Fungus from Blood Samples
  Broad-Base Antimicrobial Infusion
Aerobic Exercise

Branched-Chain Amino Acid Supplementation
Melatonin Supplementation
Chlorella Supplementation
Serotonin Receptor Antagonists

Live Cell Injections
Chart 1
Chart 1A
Chart 2
Chart 3
Chart 4
Chart 5
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Chart 7
Chart 8
Chart 9
Chart 10
Chart 11

Chart 12
Chart 13
Chart 14

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11A
Figure 11B
Figure 11C
Figure 12

Photo 1
Photo 2
Photo 3
Photo 4
Photo 5
Basic Statistics of Fibromyalgia
Common Symptoms and Characteristics of Fibromyalgia
Infection by Mycoplasma in Fibromyalgia Patients
Virus and Bacteria in Fibromyalgia Patients
Fungi Associated with Fibromyalgia and Other Pathologies
Activities of Cyclopiazonic Acid, Gliotoxin, Adenophostins
Additional Symptoms of Fibromyalgia
Comparison of Fibromyalgia and Fungemia Symptoms
Pre-Therapy Considerations
Post-Therapy Considerations for FMS -90 Days

Fibromyalgia Therapy
Ingles Integrative Hospital Antimicrobial Protocol Dosage
and Administration

Outcome from Open Clinical Study

Risk Factors for Reoccurrence

Bilayer Lipid Membrane
Nerve Transmission Through Synapse
Mechanism of Pain in Fibromyalgia
A Hydrogen Bond
Amino Acid Sequence and Conformation of the Peptide "Substance P"
Inhibition of Lymphocyte Binding of Bacteria by Substance P
Alteration of Calcium Metabolism by Mycotoxins
Release of Calcium from Sarcoplasmic Reticulum by Fungal Adenophostins

Inhibition of Muscle ATP Generation from Phosphocreatin by Gliotoxin
The Multiple Effects of Fungemia in Humans
Mycotoxins Found in Some Common Fungi.
Cyclopiazonic Acid is an Internal Salt
Inactivation of Enzymes and Protein by Gliotoxin

FMS Patient Response to Antimicrobial Protocol (Pain Relief)

Mycoplasma Invagination on RBC
Black Fungus
Candida (White Fungus)

Bacterial Invagination on RBC (Chlamydia)
HLB® Black Bridges

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