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From the Townsend Letter
November 2008

Electric Autoimmunity
Etiology and basis for nontoxic intervention in autoimmune diseases
by Mark Squibb

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A novel view of cause and cofactors in autoimmune dysregulation in Rheumatoid Arthritis, Multiple Sclerosis, Ankylosing Spondylitis, Lupus and other autoimmune syndromes. This article presents an integrated view of cellular energetic factors participate autoimmune targeting with B-Cell lines through Tumor Necrosis Factor targeting common to autoimmune disease.

Cells are electrical devices.

This article presents an electrically oriented view of the cell, with particular focus on the cell membrane. Autoimmunity, as conducted by lymphocytes, B-Cells, T-Cells, and Natural Killer cells, generally involves interactions of these cells with physical contact to evaluate the health of other cells.

Figure 1: An immune cell

Autoimmunity is the army of cells that patrol, evaluate, and eliminate "foreign" and "disruptive" elements, in the continuing process of life and health. The traditional view that these cellular interactions are chemical, and not electrical, is strikingly limited. This article suggests the novel view that most autoimmune disorders reflect a combination auto-electrical dysfunctions combined with immunological insufficiency against an undiagnosed pathogen.

Figure 2: Erythrocytes & WBC

This article presents the view that autoimmune interactions are interactions are electrical, magnetic, and paramagnetic, and chemical in nature. Modern research provides at least 15 different field phenomenon, which in aggregate enable a strikingly different modeling for immunological cellular interaction.

Figure 3: Magnetic Spin Illustration

The traditional view that autoimmunity is chemically mediated – and the near absence of curative progress in treatment of autoimmune diseases – suggests that research and treatment, are misdirected. The purpose of this document is to open a new chapter in autoimmune modeling.

The Cell Membrane
The cell membrane is the outside shell of the cell. It is very thin, ranging from 3-8 nanometers. It hosts millions or billions of chemical structures that implement the cell's role in the body.

Figure 4: Bilayer Membrane

The substrate is made of special lipids or fats, which separate the inside of the cell from the outside of the cell in a bilayer membrane. The membrane is special because it is chemical and electrical.

Membranes are structural components of cells, fatty skeletons separating water compartments. The exterior membrane encapsulates the exterior of the cell and interfaces to cell-to-body functions.

Figure 5: Cell Membrane

The external membrane encapsulates the cell, which in turn houses many other structures, many of which are encased in cell membrane material.

Phospholipid structures provide the structure of the mitochondria, which produce energy. In other words, cell membrane material is a functional structure, providing both form and function to exterior and interior cellular functions, including multiple energy production processes.

Here is a link to a truly excellent compilation of mitochondrial function sponsored by Dr's Clark and Cargile. This is a 22,000 article compilation of about 120,000 references. It is the place to start learning about cellular energy production.

As an electrical element, the cell membrane is a semiconductor, a capacitor, a resistor, and a battery. As a chemical entity, it is simply indescribable.

The Basis of Power
The cell membrane is a chemical and electrical insulator. The inside and outside of the membrane each host a pH differential. The pH differential creates a voltage, or electricity. This electricity is the power source for many essential functions in the cell membrane.

Figure 6: Chemical Battery

Anything that compromises the cell membrane power is a probable cause or cofactor in cellular malfunction.

Compromise of either the cell membrane quality or the transmembrane pH differential inhibits the electrical functions of the cell and prevents optimal cell function.

Figure 7: Capacitor

The intracellular and extracellular pH differential creates a voltage that provides chemical potential or battery for cell membrane functions. This power supply is the essential basis for hormone regulation, anabolic energy production, and ionic cellular respiration.

Anything that causes the cell membrane to leak electricity drains power. Both inadequate pH differential, and power leaks caused by garbage lodged in membrane structures, interfere with cellular functions that require power. When cell membrane power is down due to lipid toxins or pH imbalances, cell just don't work. When cells don't work, the body doesn't work.

Figure 8: Cell with internal lipid structures

There are three main aspects of cell-membrane power production:
1. The lipid substrate – must insulate the inside and outside and not leak power;
2. The pH differential – must be balanced to enable electricity, just like a car battery;
3. Raw Materials -- must be present to create chemical and electrical structures needed for the cell to work.

pH Culture
A cell's pH is utterly important because it enables the cell to produce electrical power to drive membrane functions.

There is a tendency in health care to focus on pH without considering the membrane integrity. Singular focus on water chemistry tends to leave a big part of many people's health problems improved, but unresolved.

Figure 9: pH of common substances

Both pH and water chemistry are relatively easy to shift because the body's water compartments tend to quickly exchange. Water-related protocols produce beneficial, but short-term, results because they temporarily compensate for other more structural or lipid dysfunctions. In other words, water nutrient protocols increase cell voltage by temporarily improving the ability to maintain pH inside and outside the cell.

Figure 10: Molecular binding

Unfortunately, water chemistry leaves the cellular structural garbage in place, resulting in a tendency for short-term benefits. Clearing both the membrane toxins and the sources and restoring the cellular process of automatic cleansing is critical to the durable restoration of cellular health.

Autoimmune Dysregulation
The autoimmune system protects the body from invasion and keeps friendly organisms under control.The autoimmune system uses a library of invader-sensing capabilities. It responds to invading pathogens or overgrowth of symbiotic organisms, cells, bacteria, yeast, and fungi, using many different and often barely understood sensing mechanisms.

Figure 11: Autoimmune Memory Cells

Various forms of white blood cells, lymphocytes, patrol the body continuously looking for imbalanced cells or organisms. Immune patrol lymphocytes, B-Cells, and T-Cells, and Natural Killer Cells maintain constant guard for invading or overgrown errant organisms.

Figure 12: Representation of TNF Alpha

Tumor Necrosis Factor Alpha is a member of the TNF family of cytokines. This family of cytokines tag cells for destruction by the immune system. They are created by macrophages and other immune system cells.

TNF-Alpha are a special class of proteins called transmembrane proteins. In simple terms, they reach through the cell membrane. The transmembrane protein and transmembrane potential share the membrane dimension.

Figure 13: Transmembrane Structures span cell membrane

This author suggests that the TNF triggers apoptosis (cell death) when a cell membrane voltage drops below a trigger threshold. TNF is therefore a defense mechanism against diseases that result from cells that cannot maintain membrane power.

Electrically Mediated TNF Cancer Response
Healthy cells exist with a transmembrane potential of about 70 mV. Cancer cells have a membrane potential from 15-30 mV. Since cancer cells exist below the apoptosis trigger voltage, TNF is a front line defense for cancer. TNF was named after it main role, triggering death of cancer cells because of low cell membrane voltage.

TNF and Autoimmune Dysfunction
When cells membrane integrity deteriorates to a level near or below the TNF activation, the autoimmune targeting of seemingly healthy cells occurs, resulting in various autoimmune diseases. Tissues targeted by autoimmune diseases tend to share relatively low levels of oxygenation, as well as elevated cellular parasitism.

Individuals exposed to PEMF, or electromagnetic therapies, exhibit often striking recoveries when energetics restore cellular immunity. Pulsed fields in the range of 200 nS, with intensity from 2-5 Tesla, often produce durable symptomatic reversal in less than six months. Most subjects exhibit significant decrease in joint deformation over about a four-month period.

After four months

Recovery is the likely result of healing that appears to result because of decrease in sustained absence of localized autoimmune activity, likely resulting from increased electro-positive resistance to cellular parasites and probable energetic disadvantage to the pathogens.

These results were the probable result of synergistic effects:
· Each exposure improved the transmembrane potential for a period of one to three days, likely resulting in a tendency to inhibit autoimmune TNF targeting;
· PEMF exposure increases tissue oxygen availability through a variety of means, likely resulting in improved tissue oxygenation, which enabled healing that would not have been otherwise possible;
· PEMF exposure was not limited to the hands, and the results were consistent throughout the body.

PEMF Cellular Effect Model
Pulsed electromagnetic fields create a significant turbulence at the cellular level. Brief, sub-microsecond pulses generated when electricity bridges a gap cause a short current to traverse a wire. The short current causes a tendency for electricity to flow opposite the current in the wire near the exposure. The result is a forward/backward electricity flow in the tissues near the wire.

Figure 14: PEMF Coupling
Figure 15: Magnetic Field around a Wire

Cells in the vicinity of the wire appear to absorb energy, usually obtaining a durable increase in transmembrane potential normally observed as apparent performance improvement in cell energetic structures, including, but not limited to, TNF signaling.

In Vivo Pasteurization
Pulsed fields also exhibit destructive stress on certain microorganisms. Click the links below to review National Institutes of Health (NIH) references that indicate functional deactivation of various microorganisms in food products:
· Saccharomyces cerevisiae, Alternate Article
· Salmonella Enteritidis
· Salmonella Enteritidis, E. coli and L. monocytogenes
· Escherichia coli, Listeria innocua and Saccharomyces cerevisiae
· Listeria Monocytogenes
· Escherichia coli, Salmonella Typhimurium and Listeria innocua
· Pseudomonas Fluorescens
· Lactobacillus plantarum
· Killing of Microorganisms by pulsed electric fields
· Mycobacterium paratuberculosis

Alert readers may perceive that the anti-microorganism effects of pulsed fields are likely not limited to food products. These research references strongly suggest that microbial deactivation is a by-product of PEMF exposure. The results of the exposure are generally as follows:
· Proportional to the intensity of the PEMF pulse;
· Inversely proportional to the duration of the PEMF pulses – shorter pulses exhibit stronger anti-microbial effects.

In other words, high-intensity short pulses do a better job of disrupting microbial life cycle than low-intensity, long-duration pulses.

Figure 16: Pulse Waveform

PEMF exposure has the likely co-benefit of inhibiting pathogenic microbes, hence reducing the load on the autoimmune system.

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Author note: Artwork in this document is reproduced under GPL License and may be reproduced from original sources at


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