never really thought twice about food coloring – and if I
did, I thought how wonderful it was. Isn't it great that you
can make a green cake, decorate Easter eggs, customize treats for children,
make play dough, etc.? It seemed as if every label I checked had some
type of food coloring in it, so that meant it was safe right? Unfortunately,
the answer turned out to be a resounding NO!
Why was it that some members of my family reacted after eating foods
that contained coloring? Was it my imagination? Was it something else
in the food? What about other children whose parents shared the same
concern? Why did one child become hyperactive while another broke out
in a rash? These questions haunted me, and I needed to find answers.
When we approached our pediatrician, she mentioned that some parents
believe there is a connection between colors and behavior and illness,
but there was
absolutely no evidence to support that food coloring was in any way responsible
for either outcome. However, she also was not able to provide data supporting
that it was not detrimental, so I decided to keep looking. Eventually I heard
of Dr. Ben Feingold, purchased his books, and read about the link he had made
between hyperactivity and food coloring. A number of his patients improved
or recovered by changing their diets, specifically eliminating salicylates
and colorings. Dr. Feingold had quite a bit of data on salicylates, but what
really intrigued me was the link between colors and hyperactivity – what
exactly was in these colors?
Artificial food colorings were first introduced after World War II when the
chemical industry met with the food industry regarding using chemical-based
colors since they were lower in cost than natural colors and had a longer shelf
life. The safety of the colors was determined primarily from using LD-50 tests,
and the amount was then extrapolated to humans. At the time of approval, behavioral
toxicology testing was not required by the Food and Drug Administration (FDA)
and therefore was not done on the artificial food colors.1
The Food and Drug Administration and Food Colorings
The FDA's website proved to be a valuable database for food coloring
information. The site provides precise lists of color ingredients and is quite
disturbing. I was personally horrified to learn that all artificial food colorings
contain heavy metals such as lead and mercury as well as a myriad of chemicals.
One reason this was so disturbing was that one portion of the FDA had complete
literature on the dangers of lead and the sources; however, food coloring was
not listed as a potential source of exposure. Another reason this was disturbing
was the consideration of all the possibilities for exposure to artificial food
colorings in any given day. For example, is your child drinking a sports drink
or a fruit juice with coloring? Does their antibiotic contain coloring? What
about the macaroni and cheese you made for dinner last night? What are the
cumulative effects of this exposure?
What Levels Are Safe?
Most artificial food coloring contains lead, mercury, and arsenic. What amounts
of these substances are considered safe? The Department of Health and Human
Services reports minimal risk levels (Table 1).
Table 1: Minimal Risk
Levels for Mercury, Lead, and Arsenic
|Mercuric Chloride (oral)
||Acute: .007 mg/kg/day
Intermediate: .002 mg/kg/day
||Chronic: 0.0002 mg/m3 (mg per cubic meter of air)
||EPA:1.5 mcg/ m3
WHO: .5 mcg/ m3
||Children 10 mcg/dL
OSHA – written notification & medical
exam: 40 mcg/dL
OSHA – medical removal from exposure 50 mcg/DL
||FDA: Bottled drinking water: .005 mg/L
||Acute: .005 mg/day
Chronic: .0003 mg/day
Artificial colors become even more of a concern because, not only are they
in our food products, but they are also in other daily use items such as
lotion, shampoo, soaps, etc. Furthermore, the metal allotments in these cosmetic
products are even higher than those allowed in food products. Table 2 provides
metal and chemical information for each color used in food products. Table
3 provides the same information for each color used in cosmetic products.
Table 2: Artificial Food
Coloring (81KB .pdf)
All the colorings listed in the Tables are approved for general use
in food with the exception of two colors. The first color, Orange B,
is authorized for use only in casings or surfaces of frankfurters or
sausages. Were you aware that these foods had colors in them? I certainly
was not, and that is very concerning. Even if you are consciously trying
to avoid colors, you have to be extremely vigilant and check every
label, because colors show up in seemingly innocent places.
The second color, Citrus Red No. 2, is approved only for orange skins
that are not intended for or used in processing – this means
the oranges that we are going to sit down and eat. Again, here we are
as parents, providing
what we believe is a nutritious alternative for our children, only to learn
that they can be laced with heavy metals.
What do baby shampoos, lotions, and washes have in common? They are considered
cosmetics and therefore can use FDA approved cosmetic coloring in their products.
What is interesting is the FDA has allowed for higher levels of metals in the
cosmetics category. Table 3 presents the data for cosmetic coloring.
Table 3: Artificial Cosmetic
Coloring (127KB .pdf)
According to the Children's Environmental Health Project, dermal absorption
is proportional to the concentration of the substance and the surface area
to which the substance is applied. Dermal absorption rates vary from person
to person and are affected by variables such as skin thickness, occlusions,
and the composition of the substance. Composition refers to if the substance
is lipid-soluble. If it is, it will be more easily absorbed into the skin.4
This is such an important point because this means we have to be as vigilant
about what we put on our skin as we are about what we are eating. In addition,
most of the cosmetic colorings actually allow for higher concentrations of
heavy metals and, if the dermal absorption rate varies from person to person,
the amount of toxic substances could affect some individuals more so than others.
Something as innocent as washing your hands with soap could be exposing you
to more than you bargained, and identifying alternatives needs to be a priority.
There are several studies on PubMed that considered percutaneous absorption
of lead. One study looked at inorganic lead compounds, and the conclusion of
the study was that significant amounts of inorganic lead compounds can be absorbed
through the skin and protection should be used.5 Another study looked at inorganic
lead compounds and the effectiveness of skin cleansers at removing lead from
the skin. Their results showed it is necessary to prevent skin contamination
from occurring, because a short contact can increase skin content and penetration,
even if quickly followed by washing.6
Furthermore, E-medicine reports that
transdermal absorption for alkyl lead can be substantial.
Mercurial ointments were used as a treatment for syphilis before the discovery
of penicillin. The ointments were applied directly to the thinnest areas of
the skin such as the groin and the bends of the elbows and knees. Some scientists
believed that the dermal absorption of the ointment was quite low and that
patients were actually receiving benefit from inhaling the mercury vapor. A
study was performed where the ointment was rubbed in and any excess was washed
off the skin, eliminating any source of mercury vapor. Seventy-five percent
of the study participants experienced salivation – one of the known effects
of mercury – proving dermal absorption played a key role.7
According to the Department of Health and Human Services, dermal absorption
of arsenic is low; however, it is readily absorbed if inhaled or ingested.
Many wood-based playground structures have been removed out of fears that children
would touch the arsenic-treated wood and then put their hands in their mouths.
Colors and Mental Health
As mentioned previously, Dr. Feingold identified a link between food coloring
and hyperactivity. He also noticed a marked increase in the ADD/ADHD classification
after the mass introduction of food colorings into our society. A brochure,
available in my pediatrician's office, by McNeil Consumer & Specialty
Pharmaceuticals indicates that lead exposure can lead to ADHD, yet the brochure
writers discredit the idea that food/cosmetic colors have any role in affecting
children's behavior.8 If lead has been implicated in ADHD, and
colorings have lead in them, then removing coloring additives from the diet
and environment are
crucial. The Journal of Developmental & Behavioral Pediatrics published
information regarding 15 trials with 219 participants; all were double-blind
cross-over trials. Just by eliminating artificial food colorings from their
diet, children's behavior improved significantly. Furthermore, just eliminating
food colorings from the diet produced one-third to one-half the improvement
typically seen with ADHD medication therapy.9
Even if one elects to use medication, heavy metal toxicity screenings need
to be prescribed prior to psychoactive drugs, because most of these drugs contain
colors that can lead to further toxicity. Table 4 provides an account of the
coloring present in commonly prescribed ADHD medications.
Table 4: Color Content in ADHD Medications
|Ritalin 5mg and 20 mg
||D&C Yellow No. 10
|Ritalin 10 mg
||FD&C Green No.3
||FD&C Blue No. 2, synthetic yellow iron oxide, and edible
||FD&C Yellow No. 5 and FD&C Yellow No. 6
This means that children taking these drugs are being exposed to lead, arsenic,
and mercury. This also indicates that these children in particular need to
be extremely careful with whatever medications they may take – acetaminophen,
ibuprofen, antibiotics, etc., to ensure that alternative products that do
not contain food dyes are selected. Amoxicillin11 and Cefzil,12 for example, contain
Federal Food, Drug, and Cosmetic-approved red dyes as well as aspartame. As
parents, we can check food labels, but we must rely on our physicians to select
our medicines, since the bottles provided by the pharmacist do not list the
ingredients. Colloidal silver, homeopathy, and supplements may provide a safer
Several studies also point to the link between lead and ADHD. One of the most
recent was published in the Journal of Environmental
According to the Journal, children with blood lead levels of more than two
micrograms per deciliter were four times more likely to be diagnosed with ADHD
than children with levels below .8 microgram per deciliter. The government's
acceptable blood lead level is ten micrograms per deciliter. The study estimates
that more than five million four-to-15 year olds in the US have levels higher
than two micrograms per deciliter.
Another study done by the National Academy of Sciences in 2000 stated that
roughly three percent of all developmental and neurological disorders in
the US are caused by toxic chemicals and other environmental factors. The
study showed that environmental triggers, along with a genetic predisposition,
may cause approximately 25% of developmental and neurological deficits. The
Academy also acknowledged that, in this study, they were only referring to
well-recognized and clinically diagnosed mental and physical disabilities – therefore,
the 25% estimate may in fact be higher.14
What is Your Child Exposed to on a Daily Basis?
A Day in the Life of a Child
Most parents I speak to are completely unaware of the color content
of their food, cosmetic products, and medicines. Some who are aware
are shocked to find
out coloring doesn't come from natural substances. Tables 5-7 offer color
information regarding some popular foods, cosmetics, and over-the-counter (OTC)
supplementation/medicines used for children.
Table 5: Coloring in Food Items
|Gatorade Fruit Punch
||Red 40 Lake, Blue 2 Lake, Yellow 5, Yellow 6, Blue 1 Lake, Red
40, Blue 1
|Bakery mini chocolate muffin
||FD&C Red 40
|Kraft Macaroni & cheese
||YELLOW 5, YELLOW 6
||Yellow #5, Yellow #6
||Red No. 40, Blue No. 2, Yellow No. 6, Blue No. 1
|Dannon Sprinkl'ins Yogurt15
||Yellow 6, Yellow 5, Red 40, Blue 1, Yellow 6 Lake, Red 3, Red
40 Lake, Yellow 5 Lake, Blue 2 Lake, Blue 1, Blue 1 Lake, Blue
|Nutrigrain Blueberry bars
||Red 40, Blue 1
|Strawberry Pop tarts
||Red 40, Yellow 6, Blue 1
Table 6: Coloring in Cosmetic Items
|Bathtime Colorblast Tablets
||FD&C Yellow #5, FD&C Blue #!, D&C Red #33
|Johnson Baby Shampoo
||D&C Yellow #10, D&C Orange #4
|Johnson Baby Lotion
||D&C Red 33
|Pampers hand soap
||Yellow 5, Green 5, Orange 4
|Dora Foam Soap
||May contain FD&C Blue 1, FD&C Red 40, FD&C Yellow
|Sesame Street Foam Soap
||FD&C # 33
||D&C Red No. , FD&C Blue 1 alum lk
|Crest Kids Sparkle Paste
||FD&C Blue #1
Table 7: Coloring in OTC Supplementation/Medicines
|Flintstones Vitamins (also contain aspartame)
||FD&C Red #40 Al Lake, FD&C Yellow 6 Al Lake FD&C
|Tylenol Plus Cold Infant Drops
||Red #33 and Red 40
|Delsym Cough Medicine
||FD&C Yellow 6
Cumulative Effects of Exposure?
What are the cumulative effects of food and cosmetic colorings to us and, more
importantly, to our children? According to Dr. Gary Gordon,16 each time a
manufacturer prepares a batch of dye for use in its products, it has to submit
a sample from that batch to the FDA for certification. Only the FDA can certify
colors as safe; no one else has that authority. I was unable to find any
studies indicating overall exposure or estimated daily exposure to these
metals. I was also unable to find any studies on the mixing of food colorings
or the total amount of lead, mercury, arsenic content for products that use
a combination of colors. This is concerning.
Colors in Your Cleaners
Cleaning products present an interesting challenge, since manufacturers do
not have to identify the ingredients of their products on the labels. Material
Safety Data Sheets (MSDS) are available for consumers to view via most companies' websites.
However, these MSDS require manufacturers to provide information regarding
established exposure limits. They do not provide an ingredient list and are
protected by patent laws.
The Effects of Lead, Mercury, and Arsenic
We have all heard that lead is associated with lower IQ, but did you know it
could also be responsible for some cavities? According to a study published
in the Journal of the American Medical Association (June 23/30; 281:2294),
where data was analyzed from 24,901 children, a correlation between lead and
cavities were established. Most of the children participating in the study
had blood-lead levels of only a few micrograms of lead per deciliter, well
below the federal guideline for blood-lead concentrations of 10 mcg per deciliter.
For children aged five to 17, an increased burden of 5 mcg per deciliter of
blood corresponded to an 80% increase in cavities. The researchers estimate
that cavities of 2.7 million US children result from lead, about ten percent
of all cases in that age group. The researchers speculated that either the
lead stunts development of the glands that produce saliva (which protects teeth
from harmful acid and bacteria) or lead might hinder enamel growth.17
The American Academy of Child and Adolescent Psychiatry estimates one out of
every six children in the United States has blood lead levels in the toxic
Lead exposure has been linked to developmental delays, peripheral neuropathy,
altered thyroid hormone, and reduced fertility. In elderly adults, levels over
4 mcgs can have neurobehavioral effects.
So what do you do if you get a cavity? Well, some dentists will fill your teeth
with amalgams that contain mercury. Mercury has been implicated in autism,
ADHD, learning disabilities, endocrine problems, allergies, asthma, rheumatoid
arthritis, and a host of other disorders. According to the FDA, "The
toxicity of mercury compounds is extensively documented in scientific literature.
It is well-known that mercury compounds are readily absorbed through unbroken
skin as well as through the lungs by inhalation and by intestinal absorption
after ingestion. Mercury is absorbed from topical application and is accumulated
in the body, giving rise to numerous adverse effects… Recently it has
also been determined that microorganisms in the environment can convert various
forms of mercury into highly toxic methyl mercury which has been found in the
food supply and is now considered to be a serious environmental problem."19
Common Dreams newswire reported in 2004 that Environmental Protection Agency
(EPA) scientists using data collected by the Centers for Disease Control (CDC)
estimated that one in six pregnant women has enough mercury in her blood to
pose a risk of brain damage to her developing child.20 Lower levels of mercury
exposure can lead to symptoms of fever, insomnia, rapidly changing moods, and
Arsenic poisoning has been associated with respiratory, neurological, developmental,
and cardiovascular issues. It has also been associated with cancer. In fact,
an increased risk of skin cancer in humans is associated with chronic exposure
to inorganic arsenic in medication, contaminated water, and the workplace.21
Arsenic is present in food such as meat, fish, and poultry and, according to
the Department of Health and Human Services, accounts for 80% of our dietary
intake (although fish arsenic has a low toxicity in humans and is excreted
rapidly in our urine). Fungicides, herbicides, insecticides, paints, and water
are other sources of exposure.
An intellectual function study which included 201 children under the age of
ten concluded that as little as .0017 mg per day affected children's
performance in switching attention task. When the exposure increased to .0034
mg per day, the children showed decreased performance in both switching attention
tasks as well as in tests that measured memory.22
What Can We Do?
The first step is to remove colors from your environment. This can be difficult
since colors are pervasive, but there are alternatives. For instance, if you
need food coloring, health food stores sell colors made from food – turmeric,
blueberry, beets, etc. These can be used to make play dough as well as to color
foods. Health food stores also make available muffins, toothpastes, snacks,
chocolates, drinks, and OTC medications that do not contain colors.
Cooking and eating as many meals as possible at home is also a step in the
right direction. You can control what you put in your food. If you need to
obtain medication and are not sure if it contains colors, you can check online
at www.rxlist.com. If your medication is made with colors, contact a compounding
pharmacy to see if they can compound without all the colors. A list of compounding
pharmacies can be found at www.iacprx.org.
C. Lindgren, CIHom, BA, MBA
1. Pressinger, R. Chemical Food
Additive Exposure During Pregnancy Links to Learning Disabilities,
ADD and Behavior
of South Florida Special Education Department (online). Available at:
http://www.chem-tox.com/pregnancy/artificial.htm. Accessed October
2. Food and Drug Administration (online). Available at: www.cfsan.fda.gov/~dms/opa-col2.html#table1A Accessed
June 10, 2005 and October 14, 2006.
3. Food and Drug Administration (online). Available at: www.cfsan.fda.gov/~dms/opa-col2.html#table1A Accessed
June 10, 2005 and October 14, 2006.
4. Canadian Association of Physicians for the Environment (online). Available
at: www.cape.ca/children/derm.html Accessed September 13, 2006.
5. Sun CC, et al. Percutaneous absorption of inorganic lead compounds. American
Industrial Hygiene Association 2002 Sep-Oct; 63(5):641-6.
6. Filon, et al. Skin absorption of inorganic lead (PbO) and the effect of
skin cleansers. Journal of Occupational and Environmental Medicine. 2006 Jul;48(7):692-9.
7. Scheindlin, Transdermal Drug Delivery: Past, Present, Future. Molecular
Interventions (online). Dec. 2004, Vol.4 Iss. 6. Available at: http://molinterv.aspetjournals.org/cgi/content/full/4/6/308 Accessed: August 1, 2006.
8. McNeil Consumer & Specialty Pharmaceuticals, ADHD: Answers from the
Experts, Science Made Simple. Brochure.
9. Schab, D.W., Trinh, N.H. Do Artificial Food Colors Promote Hyperactivity
in Chilcren with Hyperactive syndromes? Journal of Developmental & Behavioral
Pediatric (2004)s. 25(6) 423-434 (online). Available at: http://www.fabresearch.org/view_item.aspx?item_id=789.
Accessed October 27, 2006.
10. Available at: www.rxlist.com/cgi/generic/methphen.htm Accessed on November
11. Available at: http://www.rxlist.com/cgi/generic/amox.htm Acessed on November
12. Available at: http://www.rxlist.com/cgi/generic/cefprozi.htm Accessed on
November 8, 2006.
13. Braune, J., et al. Exposure to Environmental Toxicants and Attention Deficit
Hyperactivity in Children. Enviornmental Health Perspectives (online) . 2006
Dec. Volume 114, Number 12. Available at: http://www.ehponline.org/members/2006/9478/9478.pdf (507
Accessed on October 14, 2006
14. National Environmental Trust (online) Available at: http://www.net.org/health/neighborhood/cehfuture/intro.vtml Accessed on June 24, 2006.
15. Food Facts (online). Available at: http://www.foodfacts.com/members/item_info.cfm?id=18211 Accessed
on November 2, 2006
16. Gordon, G. Gordon Research Institute (online). Available at: http://www.gordonresearch.com/answers/lead_in_cosmetics_an_urban_legend.html Acessed on September 30, 2006.
17. Carpenter S. Lead and Bad Diet Give a Kick in the Teeth. Science News Online.
Available at: http://www.sciencenews.org/pages/sn_arc99/6_26_99/fob3.htm Acessed
on August 27, 2006.
18. American Academy of Child and Adolescent Psychiatry. Facts for Families:
Lead Exposure, 1997 (online). Available at: http://www.healing-arts.org/children/ADHD/lead.htm Acessed June 1, 2006.
19. Food and Drug Administration (online). Available at: www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?
CFRPart=700&showFR=1&subpartNode=21:18.104.22.168.10.2 (All one link.)
Accessed: August 10, 2005 and September 10, 2006.
20. Bender, M. FDA Not Protecting Children From Mercury in Fish, Say Advocates,
According to New Research. Common Dreams Newscenter (online). http://www.commondreams.org/news2004/0205-14.htm Acessed: October 3, 2007
21. Case Study in Environmental Medicine. Agency for Toxic Substances and Disease
Registry (online). Available at: http://www.atsdr.cdc.gov/HEC/CSEM/arsenic/physiologic_effects.html Acessed on November 4, 2007.
22. Wasserman, G. Water Arsenic Exposure and Children's Intellectual
Function in Araihazar, Bangladesh. Environmental Health Perspective. Available
at: http://www.ehponline.org/members/2004/6964/6964.pdf (172KB
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