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From the Townsend Letter
July 2015

Advanced 2015 Babesia Care:
Profound Testing Defects and Preventing Disability and Death
by James Schaller, MD, MAR, and Kimberly Mountjoy, MS
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Notes
1.   Schaller J. A Laboratory Guide to Human Babesia Hematology Forms. Tampa, FL: Hope Academic Press; 2008.
2.   Schaller J. Babesia Update 2009. Tampa, FL: Hope Academic Press; 2008.
3.   Schaller J. The Health Care Professional's Guide to the Treatment and Diagnosis of Human Babesiosis. Tampa, FL: Hope Academic Press; 2006.
4.   Schaller J, Mountjoy K. Checklists for Bartonella, Babesia, and Lyme Disease. Naples, FL: International Academic Infection Research Press; 2012.
5.   Parasites – babesiosis [Web page]. CDC. http://www.cdc.gov/parasites/babesiosis/disease.html. Accessed April 9, 2015.
6.   Mylonakis E. When to suspect and how to monitor babesiosis. Am Fam Physician. 2001 May 15;63(10):1969–1975. Available at www.aafp.org/afp/2001/0515/p1969.html.
7.   Schaller J. Babesia Update 2009. Tampa, FL: Hope Academic Press; 2008.
8.   Goddard A, Wiinberg B, Schoeman JP, Kristensen AT, Kjelgaard-Hansen M. Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy. Vet J. 2013 May;196(2):213–217. Epub 2012 Oct 23.
9.   Rafaj RB, Matijatko V, Kis I, et al. Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis. Acta Vet Hung. 2009 Jun;57(2):295–304.
10. Schaller J. Babesia Update 2009. Tampa, FL: Hope Academic Press; 2008.
11. Carod-Artal FJ. Strokes caused by infection in the tropics. [In Spanish.] Rev Neurol. 2007 Jun 16–30;44(12):755–763.
12. Frevert U, Nacer A. Fatal cerebral malaria: a venous efflux problem. Front Cell Infect Microbiol. 2014 Nov 6;4:155. eCollection 2014.
13. Stricker RB, Winger EE. Decreased CD57 lymphocyte subset in patients with chronic Lyme disease. Immunol Lett. 2001 Feb 1;76(1):43–8. PMID:11222912.
14. Nackos E, DeSancho M. Anemia and thrombocytopenia: diagnosis from the blood smear. Blood. 2014 Mar 20;123(12):1783. PMID:24783256. Available at http://www.bloodjournal.org/content/bloodjournal/123/12/1783.full.pdf.
15. Schaller JL, Burkland GA. Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate. MedGenMed. 2001 Sep 7;3(5):9.
16. Schaller JL, Burkland GA, Langhoff PJ. Are various Babesia species a missed cause for hypereosinophilia? A follow-up on the first reported case of imatinib mesylate for idiopathic hypereosinophilia. MedGenMed. 2007 Feb 27;9(1):38.
17. Schaller J. The Diagnosis, Treatment and Prevention of Bartonella. Tampa, FL: Hope Academic Press; 2008:5,30.
18. Schaller J, Mountjoy K. What You May Not Know About Bartonella, Babesia, Lyme Disease and Other Tick & Flea-Borne Infections. Naples, FL: International University Infection Research Press; 2012:34,59–63,75,101–102,119,130–131,142.
19. Schaller J, Mountjoy K. Checklists for Bartonella, Babesia, and Lyme Disease. Naples, FL: International Academic Infection Research Press; 2012:9,72,108.
20. Schaller J. Babesia Update 2009. Tampa, FL: Hope Academic Press; 2008:58–59.
21. Schaller J. Bartonella. In: Bryre J, ed.  Encyclopedia of Plagues, Pestilence and Pandemics. Westport, CT: Greenwood Press; 2008. Book endorsed by NIH director of infectious disease.
22. Schaller. Babesia. In: Bryre J, ed.  Encyclopedia of Plagues, Pestilence and Pandemics. Westport, CT: Greenwood Press; 2008. Book endorsed by NIH director of infectious disease.
23. Zhao Y, Love KR, Hall SW, Beardell FV. A fatal case of transfusion-transmitted babesiosis in the State of Delaware. Transfusion. 2009 Dec;49(12):2583–2587. Epub 2009 Nov 9. PMID: 19906041.
24. Goodell AJ, Bloch EM, Krause PJ, Custer B. Costs, consequences, and cost-effectiveness of strategies for Babesia microti donor screening of the US blood supply. Transfusion. 2014 Sep;54(9):2245–2257.
25. Lyme literate MD.
26. Schaller J, Mountjoy K. Combating Biofilms: Why Your Antibiotics and Antifungals Fail. Naples, FL: International Infectious Disease Press; 2014.
27. Krause PJ, Lepore T, Sikand VK, Gadbaw J Jr, Burke G, Telford SR 3rd, Brassard P, Pearl D, Azlanzadeh J, Christianson D, McGrath D, Spielman A. Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med. 2000 Nov 16;343(20):1454–1458.
28. Krause PJ, Spielman A, Telford SR 3rd, et al. Persistent parasitemia after acute babesiosis. N Engl J Med. 1998 Jul 16;339(3):160–165.
29. Krause PJ, Lepore T, Sikand VK, et al. Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med. 2000 Nov 16;343(20):1454–1458.
30. Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection. Clin Infect Dis. 2010 Feb 1;50(3):381–386.
31. Iguchi A, Matsuu A, Ikadai H, Talukder MH, Hikasa Y. Development of in vitro atovaquone-resistant Babesia gibsoni with a single-nucleotide polymorphism in cytb. Vet Parasitol. 2012 Apr 30;185(2–4):145–150. Epub 2011 Sep 28.
32. Schaller J. The Health Care Professionals' Guide to the Treatment and Diagnosis of Human Babesiosis. Tampa, FL: Hope Academic Press; 2006.
33. Horowitz R. Why Can't I Get Better? Solving the Mystery of Lyme and Chronic Disease. New York: St. Martin's Press; 2013.
34. Zhang Q, Zhang Y. Lyme Disease and Modern Chinese Medicine. New York: Sino-Med Research Institute; 2006.
35. Schaller J. Artemisinin, Artesunate, Artemisinic Acid and Other Derivatives of Artemisia Used for Malaria, Babesia and Cancer. Tampa, FL: Hope Academic Press; 2006.
36. Schaller J. The Health Care Professional's Guide to the Treatment and Diagnosis of Human Babesiosis. Tampa, FL: Hope Academic Press; 2006.
37. Vyas JM, Telford SR, Robbins GK. Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report. Clin Infect Dis. 2007 Dec 15;45(12):1588–1590.
38. Huang K. The Pharmacology of Chinese Herbs. 2nd ed. Boca Raton, FL: CRC Press; 1998.
39. Munkhjargal T, AbouLaila M, Terkawi MA, et al. Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasites. Am J Trop Med Hyg. 2012 Oct;87(4):681–688. Epub 2012 Aug 13.
40. Loiseau PM, Le Bras J. New drugs against parasitic diseases.[In French.] Rev Prat. 2007 Jan 31;57(2):175–182. PMID:17432522.
41. Dupouy-Camet J. New drugs for the treatment of human parasitic protozoa.[In French.] Parassitologia. 2004 Jun;46(1–2):81–84. PMID:15305692.
42. Tisserand R, Young R. Essential Oil Safety: A Guide for Health Care Professionals. 2nd ed. New York: Churchill Livingstone Elsevier; 2013.
43. Schaller J, Mountjoy K. Combating Biofilms: Why Your Antibiotics and Antifungals Fail. Naples, FL: International Infectious Disease Press; 2014.
44. Schaller J. The Health Care Professionals' Guide to the Treatment and Diagnosis of Human Babesiosis. Tampa, FL: Hope Academic Press; 2006.
45. Schaller J. Artemisinin, Artesunate, Artemisinic Acid and Other Derivatives of Artemisia Used for Malaria, Babesia and Cancer. Tampa, FL: Hope Academic Press; 2006.
46. Bocci V. Ozone: A New Medical Drug. Second Edition. New York: Springer; 2010.
47. Shallenberger F. Principles and Applications of Ozone Therapy – A Practical Guideline for Physicians. Seattle, WA: CreateSpace; 2011.
48. Langlais B, Reckhow D, Brink D. Industry Ozone in Water Treatment. Application and Engineering. AWWA Research Foundation; 1991.
49. Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011 Jan;2(1):66–70.
50. Lüddeke F, Heß S, Gallert C, Winter J, Güde H, Löffler H. Removal of total and antibiotic resistant bacteria in advanced wastewater treatment by ozonation in combination with different filtering techniques. Water Res. 2015 Feb 1;69:243–251. Epub 2014 Nov 22. PMID:25497174.
51. Tamai M, Matsushita S, Miyanohara H, et al. Antimicrobial effect of an ultrasonic levitation washer disinfector with silver electrolysis and ozone oxidation on methicillin-resistant Staphylococcus aureus. J Dermatol. 2013 Dec;40(12):1020–1026. Epub 2013 Dec 4. PMID:24304000.
52. Abdullaev IA. Application of ozonated perftoran in the treatment of spreaded peritonitis. [In Russian.] Klin Khir. 2014 Jan;(1):20–22. PMID:24923143.
53. Rodríguez ZZ, Guanche D, Alvarez RG, Rosales FH, Alonso Y, Schulz S. Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis. Inflamm Res. 2009 Jul;58(7):371–375. Epub 2009 Mar 10.

James Schaller, MD, MAR, is an top-rated physician with awards from physicians and national and international patients. He has written 6 books on Babesia and 13 books on tick infections. His newest book on biofilms is the best-selling book on the topic in the world, and the second best-seller under cystic fibrosis. He has published respected journal articles and books on cancer cures; parasites; nutrition; hormones; mystery illnesses; depression; inflammation; flea, louse-, and tick-borne infections; and a respected NIH-endorsed set of entries on Babesia, Bartonella, and Lyme disease. He is the author of over 30 books and 27 top peer-reviewed journal articles.

Kimberly Mountjoy, MS, is a chemist, researcher, and coauthor of seven books and eight peer-reviewed articles in chemistry and biochemistry. She has worked in research in industry and in respected science centers for many years. Most recently, she has been involved in hands-on patient care before joining Dr. Schaller.

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