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From the Townsend Letter
January 2007


Breakthrough Solutions in Herbal Medicine
Adaptogenic Formulas: The Way to Vitality

by Donald R. Yance, CN, MH, AHG, and Ben Tabachnik, PhD

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Page 1, 2, 3, 4, Notes

1. Wagner H, et al. Die DC und HPLC –analyze der Eleutherococcus. Planta Medica. 1982;44:193-19.
2. Farnsworth N, Walter D, Strerkoff L. Use of eleutherococcus in the USA: Problems, prospects & literature update. New data on eleutherococcus. Proceedings of the II International Symposium on Eleutherococcus. (Moscow, 1984). Vladivostok, 1986; 47-52.
3. Todorov I. Mechanism of antistress and anabolic action of eleutherococcus. In: Bioactive Compounds: Biotransformation and Biological action. New York: Nova Science Publishing, 1993;2-77.
4. The American Institute of Stress. America's #1 health problem and job stress. November 2001. Pedersen WA, Wan R, Mattson MP. Impact of aging on stress-responsive neuroendocrine systems. Mech Aging Dev. 2001, 122:963-83.
5. Brekhman II. Eleutherococcus. Leningrad: Nauka Publishers, 1968.
6. Kee Chang Huang. The Pharmacology of Chinese Herbs. Second Edition. Boca Raton, Florida: CRC Press, 1999;19-44.
7. Blokhin BN. The influence of eleutherococcus root and leaf extract on human work capacity under static and dynamic workloads. In Eleutherococcus and Other Adaptogens from Far East Plants. Vladivostok: Siberian Department of the Academy of Sciences of the USSR. 1966, 191.
8. Wahlstrom Mikael. Adaptogens: Nature's Key to Well-Being. Goteborg; Skandinavisk Bok, 1987.
9. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annual Review of Pharmacology. Volume 9. 1969.
10. Rohdewald P. flavonoids in health and disease. Rice-Evans C and Packer L (ed.) New York: Marcel Dekkar, Inc, 1998; 406.
11. Nadkarani AK. Indian Materia Medica. Bombay: Popular Prakashan, 1976;1: 1292-94.
12. Bohn B, Nebe CT, and Birr. Flow-cytometric studies with eleutherococcus senticosus extract as immunomodulatory agent. Arzeimittel-Forschung. 1987;35 (10): 1193-1196.
13. Dardymov IV. Some aspects of the mechanism of action on eleutherococcus senticoccus extract. Eleutherococcus: Strategy of the Use of New Fundamental Data. Moscow: Medexport, 1984.
14. Khatiashvili TM. Eleutherococcus and Other Adaptogens Derived from Far Eastern Plants. Vladivostok: Far East Book Publishers, 1996; 237-241.
15. Yang CS. Landau JM. Huang MT, Newmark HL, Yang CS. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annual Review of Nutrition. 2001; 21:381-406.
16. Farnsworth NF, Kingdorn AD, Soejarto D, Waller DP. Eleutherococcus senticosus: Current status as an adaptogen. Econ Med Plant Res. 1985;156-215.
17. Kuntsman. Pharmacology of leaves of eleutherococcus, eleutherococcus and other adaptogens from far east. Valdivistok. 1966;121-128.
18. Gubchenko PP, Fruentov NK. "Comparative Study of the Effectiveness of Eleutherococcus and Other Plant Adaptogens as Remedies for Increasing the Work Capacity of Flight Personnel." New Data on Eleutherococcus: Proceedings of the 2nd International Symposium on Eleutherococcus (Moscow, 1984). Vladivostok: Far East Academy of Science of the USSE. 1986;240.
19. Asano K, Takakhsi T, Kugo KH, Kuboyama M. "The Influence of Eleutherococcus on Muscle Work Capacity in Humans. New Data on Eleutherococcus; Proceedings of the 2nd International Symposium on Eleutherococcus (Moscow, 1984)." Vladivostok. Far East Academy of Sciences of the USSR. 1986;166.
20. Schezin AK, Zinkovich VI, Galanova LK. "Eleutherococcus: Proceedings of the 1st International Drivers of the Volzhsky Automibile Factory." "New Data on Eleutherococcus: Proceedings of the 1st International Symposium on Eleutherococcus (Hamburg, 1980)." Vladivostok. Far East Academy of Sciences of the USSR. 1981; 93.
21. Nomura, M, et al.. Comisin A, a lignan component of schizandra inhibits development of preneoplastic lesions in rat liver by 3-methyl-4-dimethylamino-azobenzene. Cancer Letters. 1994;76: 11-18.
22. Wagner H, Bladt S. Plant Drug Analysis: A Thin Layer Chromatography Atlas. Second Edition. Berlin: Spinger-Verlag. 1996;307.
23. Chang HM, But PP. Pharmacology and applications of Chinese materia medica, vol. 1. World Scientific, Singapore, 1986;17-31.
24. Kee Chang Huang. The Pharmacology of Chinese Herbs. Second Edition. Boca Raton, Florida: CRC Press, 1994;19-44.
25. Bensky, D, Gamble, A. Chinese Herbal Medicine Materia Medica. Seattle, Washington: Eastland Press, 1993;314-17.
26. Cook, W. The Physiomedical Dispensator. 1869; 399.
27. Felter HW, Lloyd JU. King's American Dispensatory. Eighteenth Edition. Third Revision. 1898; 485.
28. Lyon MR, Cline JC, Totosy de Zepetnek J, Shan JJ, Pang P, Benishin C. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: A pilot study. J Psychiatry Neurosci. 2001; 26(3):221-8.
29. Yuan CS, Attele AS, Wu JA. Panax quinquefolium L. inhibits thrombin-induced endothelin release. Am J Chin Med .1999;27(3-4):331-8.
30. Vuksan V, Stavro MP, Sievenpiper JL, Koo VYY, Wong E, Beljan-Zdravkovic U, Francis T, Jenkins AL, Leite LA, Josse RG, Xu Z, Vuksan V. American ginseng improves glycemia in individuals with normal glucose tolerance: Effect of dose and time escalation. Journal of the American College of Nutrition. 2000;19(6):738-744.
31. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review. 1999; 4(4): 255.
32. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001 Jun;6(3):293-302.
33. Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine. 2000 Dec;7(6):463-9.
34. Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr. 2000 Aug;72(2 Suppl):624S-36S
35. Ellingwood F. American Materia Medica. Therapeutics. Eclectic Medical Publications, 1919; 204-6.
36. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998 Fall;4(3):289-303.
37. Bone K, Mills S. Part Three: Ginseng. Principles & Practice of Phytotherapy. New York:Churchill Livingston, 418-432.
38. Syrov VN, Kurmukov AG. Anabolic activity of phytoecdisterone, isolated from Rhaponticum carthamoides. Farmokol Toksikol. 1976; 39(6):690-3.
39. Sololov S, Monogarov VD, Sobole VL et al. "The Influence of the Saponins of the Aralia Mandshurica on the Processes of Recovery on Athletes after Intensive Physical Work Loads." In Biologically Active Substances of Flora and Fauna of the Far East and Pacific Ocean. Vladivostok: Far East Scientific Center of the Academy of Science of the USSR,1971; 113-114.
40. Kazakevich VV. "The Influence of Aralia Mandshurica Tincture on the Central Nervous System." In: Medicinal Remedies of the Far East. Vladivostok: Far East Scientific Center of the Academy of Science of the USSR, 1972; 186.
41. Sedykh TN, Mesherskaya KA, Kabantsev VV, et al. "The Influences of the Aralia Mandshurica Tincture, Aminalon or Their Combination on Memorization of Tests." In New Medicinal Preparation from Plants of Siberia and the Far East. Tomsk, 1986; 132.
42. Academy of Sciences of the USSR Far East Branch, "The Soviet Far East" The USSR's Medicinal Treasury, 1990. Address of the Presidium: 50 Leninskaya, Vladivostok 690600, USSR.
43. Bensky D, Gamble A, translators. Chinese Herbal Medicine Materia Medica. Revised edition. Seattle, Washington: Eastland Press, 1993;336-7.
44. Dobriyakov U. Antistress action of the remedy from Antlers. In "Adaptation and Adaptogens." Vladivostok. 1977;132-134.
45. Pantokrin. Pharmacological Article. Ministry of Healthcare of Russia. Moscow, 1995. Official Document.
46. Wojcicki J, Samochoiewiec L, Kadlubowsky D, Lutomski, J. Studies on the Saponin fraction from the root of Aralia Mandchurica Rupr. Et Maxim. Herba Polonica. 1977; 4:285-288.
47. Hernandes D, Hancke J, Wikman, G. Evaluation of the anti-ulcer and antisecretory activities of extracts of Aralia Elata root and Schisandra Chinesis in rats. Journal of Ethnorpharmacology. 1988; 23:109-114.
48. Zhuravlev Y, Kolyada A. Araliaceae: Ginseng and others. Vladivostok, 1996;274.
49. Atal CK, Gupta OP, Raghunathan K, Dhar KL. Pharmacognosy and phytochemistry of Withania Somnifera. Central Council for Research in Indian Medicine and Homeopathy, New Delhi. 1975.
50. Kazakevich V. "The Influence of Aralia Mandchurica Tincture on the Central Nervous System." In: Medicinal Remedies of the Far East. Vladivostok: Far East Scientific Center of the Academy of Science of the USSR, 1972:186.
51. Grandhi A, Mujumdar AM, Patwardlhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol. 1994;44:131-135.
52. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol. 1999;64:91-93.
53. Devi PU. Withania somnifera Dunal (Ashwagandha): Potential plant source of a promising drug for cancer chemotherapy and radiosensitization. Indian J Exp Biol. 1996 Oct;34(10):927-32
54. Khuttan G. Use of Withania somnifera Dunal as an adjuvant during radiation therapy. Indian J Exp Biol. 1996;Sep;34(9):854-6
55. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Altern. Medicine Review. 1999; 4 (4): 255.
56. Yaremenko KV, Pashinski VG. "Preparations of Natural Origin as Remedies for Prophylactic Oncology." In New Medical Preparations from Plants of Siberia and the Far East. Tomsk, 1986;171-2.
57. Udintsev SN, Krylova SG, Formina TI. The enhancement of the efficacy of Adriamycin by using hepatoprotectors of plant origen in metastases of Ehrlich's adenocarcinoma to the liver in mice. Vopr Onkol. 1992; 38:1217-1222.
58. Stancheva SL, Mosharrof A. Effect of the extract of Rhodiola rosea L. on the content of the brain biogenic monamines. Med Physiol. 1987;40:85-87.
59. Ip SP, Che CT, Leung PS. Association of free radicals and the tissue renin-angiotensin system: Prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury. JOP. 2001 Jan;2(1):16-25.
60. Zhang Z, Liu J, Shang X, Yang J, Chu J, Wang Z, Yao Z, Ma H, Li Q, Wang Y. The effect of Rhodiola capsules on oxygen consumption of myocardium and coronary artery blood flow in dogs. Zhongguo Zhong Yao Za Zhi. 1998 Feb;23(2):104-6.
61. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue: A double-blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000 Oct;7(5):365-71.
62. Lupandin AV. "Adaptation and Rehabilitation in Sports." Khabarovsk: Institute of Physical Culture, 1991.
63. Gerasyuta M, Koval TN. "The Experience of Prolonged Use of Leuzea Carthamoides Extract for the Purposes of Preservation and Increase of Mental and Physical Work Capacity." In New Data on Eleutherococcus and Other Adaptogens: Proceedings of the 1st International Symposium on Eleutherococcus (Hamburg, 1980). Vladivostok: Far East Scientific Center of the Academy of Science of the USSR, 1981; 135.
64. Krasnov EA, Saratikov AS, Yakunina GD. Incosterone and ecdisterone from rhaponticum carthamoides. Chemistry of Natural Compounds. 1976;4:550.
65. Syrov VN, Khushbaktova ZA, Nabiev AN. An experimental study of the hepato-protective properties of phytoecdysteoids and nerobol in carbon tetrachloride-induced liver lesion. Eksp Klin Farmakol. 1992May-June; 55(3):61-65
66. Shin HR, Kim JY, Yun TK, Morgan G, Vainio H. The cancer-preventive potential of Panax ginseng: A review of human and experimental evidence. Cancer Causes Control. 2000 Jul;11(6):565-76.
67. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998 Fall;4(3):289-303.
68. Liu J, Yang S, Yang X, Chen Z, Li J. Anticarcinogenic effect and hormonal effect of Cordyceps. Zhongguo Zhong Yao Za Zhi. 1997 Feb;22(2):111-3.
69. Liu P, Zhu J, Huang Y, Liu C. Influence of Cordyceps sinensis (Berk.) Sacc. and rat serum containing same medicine on IL-1, IFN and TNF produced by rat Kupffer cells. Zhongguo Zhong Yao Za Zhi 1996 Jun;21(6):367-9, 384.
70. Koh JH, Yu KW, Suh HJ, Choi YM, Ahn TS. Activation of macrophages and the intestinal immune system by an orally administered decoction from cultured mycelia of Cordyceps sinensis. Biosci Biotechnol Biochem. 2002 Feb;66(2):407-11.
71. Gong HY, Wang KQ, Tang SG. Effects of cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B. Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):248-50.
72. Manabe N, Sugimoto M, Azuma Y, Taketomo N, Yamashita A, Tsuboi H, Tsunoo A, Kinjo N, Nian-Lai H, Miyamoto H. Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse. Jpn J Pharmacol. 1996 Jan;70(1):85-8.
73. Yamaguchi Y, Kagota S, Nakamura K, Shinozuka K, Kunitomo M. Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res. 2000 Dec;14(8):647-9.
74. Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci. 1997;60(25):2349-59.
75. Zhou DH, Lin LZ. Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):476-8.
76. Jpn J Exp Med. 1989 Aug;59(4):157-61.
77. Cancer Invest. 1994;12(6):611-5.
78. Bok JW, Lermer L, Chilton J, Klingeman HG, Towers GH. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry. 1999 Aug;51(7):891-8
79. Kee Chang Huang. The Pharmacology of Chinese Herbs. Boca Raton, Florida: CRC Press, 1999;23:263-4/
80. Balon TW, Jasman AP, Zhu JS. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. J Altern Complement Med. 2002 Jun;8(3):315-23.
81. Huang BM, Hsu CC, Tsai SJ, Sheu CC, Leu SF. Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells. Life Sci. 2001 Oct 19;69(22):2593-602.
82. Shin KH, Lim SS, Lee SH, Lee YS, Cho SY. Antioxidant and immunostimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp. Ann N Y Acad Sci. 2001 Apr;928:261-73.
83. Jones K. Reishi: Ancient Herb for Modern Times. Issaquah, WA: Sylvan Press, 1990.
84. Willard T. Reishi Mushroom: Herb of Spiritual Potency and Wonder. Issaquah, WA: Sylvan Press, 1990; 11.
85. Jianzhe Y, Xiaolan M, Qiming M, Yichen Z, Huaan W. Icons of Medicinal Fungi from China. Beijing: Science Press, 1987.
86. Kammatsuse K, Kajiware N, Hayashi K. Studies on Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi. 1985;105:531–3.
87. Jin H, Zhang G, Cao X, et al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science, 1996, 131–8.
88. Jones K. Reishi mushroom: Ancient medicine in modern times. Alt Compl Ther. 1998;4:256–66.
89. Heber D, Blackburn G, Vay LG. "Cancer Chemoprevention." In Nutritional Oncology. New York: Academic Press, 1999, Chapter 22., 1999;351.
90. Ibid.
91. Sartippour MR, Heber D, Ma J, Lu Q, Go VL, Nguyen M, Sartippour MR. Green tea and its catechins inhibit breast cancer xenografts. Nutrition & Cancer. 2001; 40(2):149-156.
92. Liao S. The medicinal action of androgens and green tea epigallocatechin gallate. Hong Kong Med J. 2001;7:369-374.
93. Higashi-Okai K, et al. Identification and antioxidant activity of several pigments from the residual green tea (Camellia sinensis) after hot water extraction. J UOEH. 2001Dec 1;23(4):335-44.
94. Sadzuka Y, et al. Enhancement of the activity of doxorubicin by inhibition of glutamate transporter. Toxicology Letter. 2001;123:159-67.
95. Hong J, et al. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochemical Pharmacology. 2001;62 (9): 1175-1183.
96. Carcinogenesis. 2002:1307-13.
97. Hasegawa N, et al. Vitamin C is one of the lipolytic substances in green tea, Phytotherapy Research. 16 Supplement 1:S91-2. 2002 August 3; 285(5): 1102-1106.
98. Tokunaga S, et al. Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan. Annals of Epidemiology. 2002Apr;12(3):157-65.
99. Tokunaga S, White IR, Frost C, Tanaka K, Kono S, Tokudome S, Akamatsu T, Moriyama T, Zakouji H. Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan. Ann Epidemiol. 2002 Apr;12(3):157-65.
100. Fassina G, et al. AIDS. 2002 Apr 12;16(6):939-41.
101. Fassina G, Buffa A, Benelli R. Varnier OE. Noonan DM, Albini A. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent. AIDS. 2002Apr 12;16(6):939-41.
102. Buetler TM, Renard M, Offord EA, Schneider H, Ruegg UT. Green tea extract decreases muscle necrosis in mdx mice and protects against reactive oxygen species. Am J Clin Nutr. 2002 Apr;75(4):749-53.
103. Jiang MC, Yang-Yen HF, Yen JJY et al. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr Cancer. 1996; 26:111-20.
104. Commandeur JNM, Vermeulen NPE. Cytotoxicity and cytoprotective activities of natural compounds: the case of curcumin. Xenobiotica. 1996; 26:667-80.
105. Anti-metastatic activity of curcumin and catechin. Menon LG; Kuttan R; Kuttan G Amala Cancer Research Centre, Trichur, India. Cancer Lett. 141(1-2):159-65 1999 Jul 1
106. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett 2001 Oct 30;172(2):111-8 (ISSN: 0304-3835) Goel A; Boland CR; Chauhan DP Division of Gastroenterology, Department of Medicine, The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0688, USA.
107. Fetrow CW, Avila JR. Professional's Hand-Book of Complementary and Alternative Medicine. Springhouse, PA: Springhouse; 1999.
108. Burnham TH, ed. Review of natural products. St. Louis: Facts and Comparisons; 1993. Charles V, Charles SX. The use and efficacy of Azadirachta indica ADR ('neem') and Curcuma longa ('turmeric') in scabies: A pilot study. Trop Geogr Med. 1992; 44:178-81.
109. Curcumin (diferuloylmethane), a singlet oxygen ((1)O(2)) quencher. Biochem Biophys Res Commun 2002 Jul 5;295(1):62-6 (ISSN: 0006-291X) Das KC; Das CK Department of Molecular Biology, University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
110. Jordan WC. Curcumin -- a natural herb with anti-HIV activity. J Natl Med Assoc. 1996; 88:333. Letter.
111. Ahsan H, Parveen N, Khan NU, Hadi SM. Chem Biol Interact. 1999 Jul;121(2):161-75. Biochem Biophys Res Commun 2002 Jul 5;295(1):62-6 (ISSN: 0006-291X) Das KC; Das CK Department of Molecular Biology, University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA.
112. Bush JA, Cheung KJ Jr, Li G. Curcumin Induces Apoptosis in Human Melanoma Cells through a Fas Receptor/Caspase-8 Pathway Independent of p53. Experimental Cell Research. 2001 December 10; 271(2):305-14.
113. Kapoor S, Priyadarsini KI. Protection of radiation-induced protein damage by curcumin. Biophys Chem. 2001 Aug 30;92(1-2):119-26.
114. Rukkumani R, Sri Balasubashini M, Vishwanathan P, Menon VP. Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia. Pharmacol Res. 2002 Sep;46(3):257-64.
115. Anuchapreeda S, Leechanachai P, Smith MM, Ambudkar SV, Limtrakul PN. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol. 2002 Aug 15;64(4):573-82.
116. Zhang F, Altorki NK, Mestre JR, Subbaramaiah K, Dannenberg AJ. Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis. 1999 Mar;20(3):445-51
117. Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Prostate. 2001 Jun 1;47(4):293-303.
118. Shao ZM. Shen ZZ. Liu CH. Sartippour MR. Go VL. Heber D. Nguyen M, Sreejayan, R. Nitric oxide scavenging by curcuminoids. Journal of Pharmacy and Pharmacology. 1997; 49 (1): 105-107.
119. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. International Journal of Cancer. 2002 Mar 10;98(2):234-40.
120. Ramachandran C; You W. Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res Treat. 1999 Apr;54(3):269-78.
121. Lim GP. Chu T, Yang F, Beech W, Frautschy SA, Cole GM.The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7. (ISSN: 1529-2401) Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA.Turmeric may block the progression of MS, The findings were presented at the Experimental Biology 2002 conference
122. Modulatory effects of curcumin on the chromosomal damage induced by doxorubicin in Chinese hamster ovary cells. Antunes LM; Ara«ujo MC; Dias FL; Takahashi CS Department of Genetics, Faculty of Medicine of Ribeir~ao Preto, University of S~ao Paulo, Brazil. Teratog Carcinog Mutagen, 19(1):1-8 1999
123. M.A. Pereira, et al. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats. Carcinogenesis. 1996;17 (6) : 1305-1311.
124. Okada K. Wangpoengtrakul C. Tanaka T. Toyokuni S. Uchida K. Osawa T. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. Journal of Nutrition. 2001 Aug;131(8):2090-5.
125. Nirmala C, Puvanakrishnan R.Protective role of curcumin against isoproterenol-induced myocardial infarction in rats. Mol Cell Biochem. 1996 Jun 21;159(2):85-93.
126. Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T, Sa G. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun. 2001 Nov 2;288(3):658-65.
127. Arbiser J. Curcumin inhibits angiogenesis in vivo. Mol Med. 1998;4:376-383.
128. Kim MS, Kang HJ, Moon A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch Pharm Res (Korea ). 2001 Aug;24(4):349-54.
129. Folts, JD. Experimental Biology, 2001, the annual meeting of the Federation of the American Societies of Experimental Biology (FASEB), Orlando, April 1, 2002/PR Newswire.
130. Dr. H. Kiesewetter, Universitatsklinikum Charite, Institute fur Transfusionsmedizin, Schumannstrae 20-21, 10117 Berlin; Germany. Good clinical practice in accordance with clinical studies on the efficacy and tolerability of red wine leaf extract in chronic venous insufficiency. Vasomed. 2002;14(1): 18-20.
131. Masquerlier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers. Acta Therap. 1981;7:101-5.
132. Corbe C, Boisin JP, and Siou A. Light vision and chorioretinal circulation. Study of the effect of OPCs (Endotelon). J Fr Ophtalmom. 1988;11:453-60.
133. Facino RM, et al. Free radical scavenging action and anti-enzyme activities of PCOs with respect to superoxide anion and lipid peroxidation. Plant Med Phytother. 1989;4:267-74.
134. Huynh HT, Teel RW. Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res. 2000 Jul-Aug.
135. Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A, Bui M, Bagchi D. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: A pilot study. J Med. 2000;31(5-6):227-46.
136. Freedman JE, Parker C 3rd, Li L, Perlman JA, Frei B, Ivanov V, Deak LR, Iafrati MD, Folts JD. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation. 2001 Jun 12;103(23):2792-8.
137. Teixeira S. Bioflavonoids – OPCs and quercetin and their potential roles in treating musculoskeletal conditions. J Orthop Sports Phys Ther. 2002;32:357-363.
138. Abstract: Alternative Medicine Review, Volume 7, Number 4, 2002.
139. Rohdewald P. Flavonoids in Health and Disease. Rice-Evans C and Packer L. Marcel Dekkar, Inc 1998; 406.
140. Gao X, Xu YX, Janakiraman N, Chapman RA, Gautam SC. Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochemical Pharmacology. 2001;62(9):1299-1308.
141. Schneider Y; Vincent F; Duranton B; Badolo L; Gosse F; Bergmann C; Seiler N; Raul F Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett. 2000 Sep 29;158(1):85-91.
142. Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin P, Castanas E. Potent inhibitory action of red wine polyphenols on human breast cancer cells. Journal of Cellular Biochemistry. 2000; 78(3): 429-441.
143. Sartippour MR, Shao ZM, Heber D, et al. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr. 2002;132:2307-2311.
144. J Nutr. 2002;132(8):2307-11.
145. Amino Acids. 2002;22(1):1-13.
146. Berger SJ, et al. Green tea constituent epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells. Biochemical and Biophysical Research Communication. 2001;288:101-105.
147. Arch Biochem Biophys. 2000 Apr 15;376(2):338-46.
148. Sazuka M, et al. Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins. Bioscience, Biotechnology, and Biochemistry. September 1997;1504-6.
149. August D, et al. Ingestion of green tea rapidly decreases prostaglandin e2 levels in rectal mucosa in humans. Cancer Epidemiology Biomarkers & Prevention. 1999;8;709-713.
150. Biochim Biophys Acta. 2002;1542(1-3):209-20/
151. Rakotoarison DA, Gressier B, Trotin F, et al. Antioxidant activities of polyphenolic extracts from flowers, in vitro callus and cell suspension cultures of Crataegus monogyna. Pharmazie. 1997;52:60-64.
152. Gabor M. Pharmacological effects of flavonoids on blood vessels. Angiologica. 1972;9:355-374.
153. Shanthi S, Parasakthy K, Deepalakshmi PD, Devaraj SN. Hypolipidemic activity of tincture of Crataegus in rats. Indian J Biochem Biophys. 1994;31:143-146.
154. Rajendran S, Deepalakshmi PD, Parasakthy K, et al. Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis. 1996;123:235 241.
155. Weikl A, Assmus KD, Neukum-Schmidt A, et al. Crataegus Special Extract WS 1442. Assessment of objective effectiveness in patients with heart failure. Fortschr Med. 1996;114:291-296.
156. Leuchtgens H. Crataegus Special Extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study. Fortschr Med. 1993;111:352-354.
157. 10.Rewerski VW, Piechocki T, Tyalski M, Lewak S. Some pharmacological properties of oligomeric procyanadin isolated from hawthorn (Crataegus oxyacantha). Arzniem Forsch. 1967;17:490-491.
158. Uchida S, Ikari N, Ohta H, et al. Inhibitory effect of condensed tannins on angiotension converting enzyme. Jap J Pharmacol. 1987;43:242-245.
159. Donald Brown's Quarterly Reveiw of Natural Medicine. Summer 1995.
160. Chen JD, Wu YZ, Tao ZL, Chen ZM, Liu XP. Hawthorn (shan zha) drink and its lowering effect on blood lipid levels in humans and rats. Institute of Sports Medicine, Beijing Medical University, China. World Rev Nutr Diet. 1995;77:147-54.
161. Guan Y, Zhao S. Yishou jiangzhi (de-blood-lipid) tablets in the treatment of hyperlipemia. J Tradit Chin Med. 1995 Sep;15(3):178-9.
162. Zakay-Rones Z, Varsarno N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra) during an outbreak of influenza B Panama. Journal of Alternative Complementary Medicine. 1995; 1:361-9.
163. Duke JA, Ayensu ES. Medicinal Plants of China. Medicinal Plants of the World. Vol. 1. Algonac, MI: Reference Publications, Inc, 1985:362.
164. Kiuchi F, Shibuya M, Sankawa U. Inhibitors of prostaglandin biosynthesis from ginger. Chem Pharm Bull (Tokyo). 1982; 30:754-7.
165. Flynn D, Rafferty M, Boctor A. Inhibition of human neutrophil 5-liopxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds. Prostaglandins Leukotrienes Med. 1986; 24:195-8.
166. Yamahara J, Miki K, Chisaka T, et al. J Ethnopharmacol. 1985; 13 (2): 217-225.
167. Eldershaw TP, Colquhoun EQ, Dora KA, et al. Ent J Obesity Relat Metab Discord. 1992; 16 (10): 755-63.
168. Kobayashi M, Ishida Y, Shoji N, Ohizumi Y. Cardiotonic action of [8]-gingerol, an activator of the Ca++-pumping adenosine triphosphatase of sarcoplasmic reticulum, in guinea pig atrial muscle. J Pharmacol Exp Ther. 1988; 246:667-73.
169. Shoji N, Iwasa A, Takemoto T, Ishida Y, Ohizumi Y. Cardiotonic principles of ginger (Zingiber officinale Roscoe). J Pharm Sci. 1982; 71:1174-5.
170. Zhou Y, Xu R. Antioxidative effect of Chinese drugs. Chung Kuo Chung Yao Tsa Chih. 1992; 17:368-9, 373.
171. Sujatha R, Srinivas L. Modulation of lipid peroxidation by dietary componenets. Toxicology in vitro. 1995; 9:231-36.
172. Guo P, Xu J, Xu S, Wang K. Inhibition of hydrogen peroxide production in chondrocytes induced by fulvic acid by ginger volatile oil. China J Chinese Materia Medica. 1997; 22:559-61.
173. Vimala S, Norhanom AW, Yadav M. Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br J Cancer. 1999; 80:110-6.
174. Murakami A, Morita H, Safitri R, Ramlan A, Koshimizu K, Ohigashi H. Screening for in vitro anti-tumorpromoting activities of edible plants from Indonesia. Cancer Detect Prev. 1998; 22:516-25.
175. Lee E, Surh Y. Induction of apoptosis in HL-60 cells by pungent vanilloids, 6-gingerol and 6-paradol. Cancer Letters. 1998; 134:163-8.
176. Surh YJ, Lee E, Lee JM. Chemoprotective properties of some pungent ingredients present in red pepper and ginger. Mutat Res. 1998; 402:259-67.
177. Hashim S, Aboobaker V, Madhubala R, Bhattacharya R, Rao A. Modulatory effects of essential oils from spices on the formation of DNA adduct by an aflatoxin B1 in vitro. Nutr Cancer. 1994; 21:169-75.
178. Glaser R, Rabin B, Cheaney M, et al. Stress-Induced Immunomodulation. Implications for Infectious Diseases? JAMA. 1999 Jun 23.30; 281(24):2268-70
179. Billac, Peter. Managing Stress Through the Magic of Adaptogens. Alvin, Texas: Swam Publishing; 1999.
180. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medicia. Seattle, Washington: Eastland Press, 1986; 387.
181. Selye H. Nature. 1936;138: 32.
182. Selye H. Nature. 1938;141: 926.
183. Bensky, D, Gamble A. Chinese Materia Medica. Seattle, Washington: Eastland Press, 1993; 223-24.
184. Lupandidn AV, Lapaev II. Schizandra. Khabarovsk Publishing, 1981;125.
185. Samilova RD. Pharmacology of adaptogens. Pharmaceutical Journal (Kiev). 1976; 6: 11-20.
186. Lupandin AV. Adaptation to extreme natural and technogenic factors in trained and untrained people under effect of adaptogens. Journal "Fiziologya cheloveka" ("Human physiology"). 1990;4:38-45.
187. Weiner M. "Schizandra." In Herbs That Heal: Prescription for Herbal Healing. 1996;292-293.
188. Ahumada F, et al. Studies on the effect of schizandra chinensis extract on horses submitted to exercise and maximum effort. Phytotherapy. 1989; 3(5):175-179.
189. Lebedev AA. Appraisal of the stimulative action of schizandra chinensis. Materials for the study of the stimulative and tonic actions of ginseng and schizandra chinensis. Moscow, Academy of Science of USSR/ 1955;182-185.
190. Sinovich VA, Akhmerova, ZB The influence of Schizandra on normal and pathological visual functions. Materials for Study of Ginseng and Schizandra (Leningrad). 1958;3:177-180.
191. Wang B-X. (1996). Advances in the research of chemistry, pharmacology and clinical application of pilose antler. Proceedings of the ‘96 International Symposium on Deer Science and Deer Products. Changchun, China. 1996; 14-32.
192. Wojcicki J, Samochoiewiec L, Kadlubowsky D, Lutomski, J. Studies on the saponin fraction from the root of aralia mandchurica rupr. et maxim. Herba Polonica. 1977;4:.285-288.
193. Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alternative Medicine Review. 1999; 4 (4):255.
194. Kee Chang Huang. The Pharmacology of Chinese Herbs. Second Edition. Boca Raton, Florida: CRC Press, 1999;19-44.
195. Brown, R, Gerbarg, P, Ramazanov Z. Rhodiola rosea, A phytomedical overview. HerbalGram 56. 2002;40-52.
196. Shechezhin AK, Zinkovich VI, Matsuk VS. Tentative data on the mass, Eleutherococcus prophylaxis of influenza at the main assembly line and metallurgical plant of the Volga Automobile plant. 2nd All-Union Conf. on the Adaptation of Man to Different Geographical, Climatic, and Industrial Conditions. Siberian Branch USSR Academy of Medical Sciences. Novosibirsk, 1977.
197. Gubchenko PP, Fruentov NK. "Comparative Study of the Effectiveness of Eleutherococcus and Other Plant Adaptogens as Remedies for Increasing the Work Capacity of Flight Personel." In New Data on Eleutherococcus: Proceedings of the 2nd International Symposium on Eleutherococcus (Moscow, 1984). Vladivostok: Far East Academy of Science of the USSR, 1986;240.
198. Fruentov NK, Lupandin AV. "On the Adaptogenic Action of Schisandra Preparations." In Processes of Adaptation and Biologically Active Substances - Proceedings of the Conference (Vladivostok, May 1972). Vladivostok: Far East Center of the Academy of Science of the USSR, 1976; 63.
199. Saratikov AS, Krasnov EA. "Clinical Studies of Rhodiola." Rhodiola Rosea is a Valuable Medicinal Plant. Tomsk: Medical Institute, Russia 1987, pg. 216.
200. Saratikov AS, Krasnov EA. "The Adaptogenic Attributes of Rhodiola." Rhodiola Rosea is a Valuable Medicinal Plant. Tomsk: Medical Institute, 1987; 194.
201. Linh PT, et al. Quantitative determination of salidroside and thyrosol from the underground part of Rhodiola rosea by high performance liquid chromatography. Arch Pharm Res. 2000Aug; 23(4): 349-52.
202. Ip SP, Mak DH, Li PC, Poon MK, Ko KM. Effect of a lignan – enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxity in rats. Pharmacol Toxicol. 1996 Jun;78 (6): 413-16.

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