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From the Townsend Letter
February / March 2016

Oxytocin: The New Hormonal Kid on the Clinical Block
by Dr. Devaki Lindsey Berkson
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Notes
1.      Earp BD, Sandberg A, Savulescu J. Natural selection, childrearing, and the ethics of marriage (and divorce): building a case for the neuroenhancement of human relationships. Philos Technol. 2012;25:561–587.
2.      Allen ES, Atkins DC, Baucom DH, et al. Intrapersonal, interpersonal, and contextual factors in engaging in and responding to extramarital involvement. Clin Psychol. 2005;12:100–130.
3.      Pew Research Center. The Decline of Marriage and the Rise of New Families. Pew Charitable Trust; 2010. http://www.pewsocialtrends.org/files/2010/11/pew-social-trends-2010-families.pdf.
4.      Any anxiety disorder among adults [Web page]. National Institute of Mental Health.  http://www.nimh.nih.gov/health/statistics/prevalence/any-anxiety-disorder-among-adults.shtml.
5.      Savulescu J, Sandberg A. Neuroenhancement of love and marriage: the chemicals between us. Neuroethics. 2008;1:31–44.
6.      Symons D. Darwinism and contemporary marriage. In: Davis K, ed. Contemporary Marriage. New York: Russell Sage; 1985:133–155.
7.      Earp BD, Sandberg A, Savulescu J. Natural selection, childrearing, and the ethics of marriage (and divorce): building a case for the neuroenhancement of human relationships. Philos Technol. 2012;25:561–587.
8.      Wudarczyk OA, Earp BD, Guastella A, Savulescu J.. Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations. Curr Opin Psychiatry. 2013 Sep; 26(5): 474–484.
9.      Devi G. A Calm Brain: How to Relax into a Stress-Free, High-Powered Life. New York: Penguin Dutton; 2012.
10.    Carter CS. Developmental consequences of oxytocin. Physiol Behav. 2003;79:383–97.10.1016/S0031-9384(03)00151–153.
11.    Kiss A, Mikkelsen JD. Oxytocin – anatomy and functional assignments: a minireview. Endocr Regul. 2005;39:97–105.
12.    Olff M, Frijling JL, Kubzansky LD, et al. The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology. 2013;38:1883.
13.    Ishak WW, Berman DS, Peters A. Male anorgasmia treated with oxytocin. J Sex Med. 2008 Apr;5(4):1022–1024.
14.    Behnia B, Heinrichs M, Bergmann W, et al. Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples. Horm Behav. 2014 Mar;65(3):308–318.
15.    Matsuzaki M, Matsushita H, Tomizawa K, Matsui H. Oxytocin: a therapeutic target for mental disorders. J Physiol Sci. 2012 Nov;62(6):441–444.
16.    Matsushita H, Matsuzaki M, Han XJ, et al. Antidepressant-like effect of Sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation. Neuroscience. 2012 Jan 3;200:13–18. doi:10.1016/j.neuroscience.2011.11.001. Epub 2011 Nov 9.
17.    Zhang Z, Klyachko V, Jackson MB. J Physiol. 2007 Oct 1;584(Pt 1):137–147. Blockade of phosphodiesterase Type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release.
18.    Acevedo-Rodriguez A, Mani SK, Handa RJ. Oxytocin and estrogen receptor β in the brain: an overview. Front Endocrinol (Lausanne). 2015 Oct 15;6:160.
19.    Onaka T. Neural pathways controlling central and peripheral oxytocin release during stress. J Neuroendocrinol. 2004;16:308–12.10.1111.
20.    Carmichael MS, Warburton VL, Dixen J, Davidson JM. Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav. 1994 Feb;23(1):59–79.
21.    Knobloch HS, Charlet A, Hoffmann LC, et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron (2012) 73:553–66.10.1016/j.neuron.2011.11.030 .
22.    Carter CS. Oxytocin pathways and the evolution of human behavior. Annu Rev Psychol. 2014;65:17–39.10.1146/annurev-psych-010213-115110.
23.    Lee HJ, MacBeth AH, Pagani JH, Young WS. Oxytocin: the great facilitator of life. Prog Neurobiol. 2009;88:127–151.
24.    Lim MM, Wang Z, Olazábal DE, et al. Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature. 2004;429:754–757.
25.    Cho MM, Courtney DeVries A, Williams JR, Carter CS. The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster) Behav Neurosci. 1999;113:1071–1079.
26.    Young LJ, Wang Z. The neurobiology of pair bonding. Nature Neurosci. 2004;7:1048–1054.
27.    Fisher H, Aron A, Brown LL. Romantic love: a mammalian brain system for mate choice. Philos Trans R Soc Lond B Biol Sci. 2006;361:2173–2186.
28.    Donaldson ZR, Young LJ. Oxytocin, vasopressin, and the neurogenetics of sociality. Science. 2008;322:900–904.
29.    Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss JJ. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain: an autoradiographic study. Brain Res. 1991;555:220–232.
30.    Knobloch HS, Charlet A, Hoffmann LC, et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron (2012) 73:553–566.10.1016/j.neuron.2011.11.030.
31.    Chiodera P, Volpi R, Capretti L, et al. Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa. Metabolism. 1991;40:1226–30.10.1016/0026-0495(91)90220-Q.
32.    Krezel W, Dupont S, Krust A, Chambon P, Chapman PF. Increased anxiety and synaptic plasticity in estrogen receptor beta-deficient mice. Proc Natl Acad Sci U S A 2001;98:12278–82.10.1073/pnas.221451898.
33.    Alvaro-Gonzalez LC. The social brain: neurobiological bases of clinical interest. Rev Neurol. 2015 Nov 16;61(10):458–470.
34.    Iwasaki Y, Maejima Y, Suyama S, et al. Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R360–369. doi:10.1152/ajpregu.00344.2014. Epub 2014 Dec 24. .
35.    Devi, G. (2012) A Calm Brain: How to Relax into a Stress-Free, High-Powered Life. New York: Penguin Dutton.
36.    Estacio MA, Tsukamura H, Yamada S, Tsukahara S, Hirunagi K, Maeda K. Vagus nerve mediates the increase in estrogen receptors in the hypothalamic paraventricular nucleus and nucleus of the solitary tract during fasting in ovariectomized rats. Neurosci Lett. 1996 Apr 12;208(1):25–28.
37.    Fisher H, Aron A, Brown LL. Romantic love: an fMRI study of a neural mechanism for mate choice. J Comp Neurol. 2005 Dec. 5;493(1):58–62.;Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss JJ. Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain: an autoradiographic study. Brain Res. 1991;555:220–232.
38.    Behnia B et al. Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples. Horm Behav. 2014 Mar;65(3):308–318.
39.    Churchland PS, Winkielman P. Modulating social behavior with oxytocin: how does it work? What does it mean? Horm Behav. 2012;61:392–399. .
40.    Carmichael MS, Warburton VL, Dixen J, Davidson JM. Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sex Behav. 1994 Feb;23(1):59–79.
41.    Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. J Clin Endocrol Metab. 1987. 64;27–31.
42.    Krüger TH, Haake P, Chereath D, et al. Specificity of the neuroendocrine response to orgasm during sexual arousal in men. J Endocrinol. 2003. Apr;177(1):57–64.
43.    Huynh HK, Willemsen AT, Holstege G. Female orgasm but not male ejaculation activates the pituitary. A PET-neuro-imaging study. Neuroimage. 2013 Aug 1;76:178–182.
44.    Klein BY, Tamir H, Hirschberg DL, et al. Oxytocin opposes bacterial endotoxin – Effects on ER-stress signaling in Caco2BB gut cells. Biochim Biophys Acta. 2015 Oct 28. pii:S0304-4165(15)00297-4.
45.    Welch MG, Margolis KG, Li Z, Gershon MD. Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G848–G862.
46. Jonasson AF, Edwall L, Uvnäs-Moberg K. Topical oxytocin reverses vaginal atrophy in postmenopausal women: a double-blind randomized pilot study. Menopause Int. 2011 Dec;17(4):120–5. doi:10.1258/mi.2011.011030. Epub 2011 Nov 25.
47.    Harrington M. .With oxytocin, old muscles act like new. Lab Anim (NY). 2014 Aug;43(8):260.
48.    Kim YR, Eom JS, Yang JW, Kang J, Treasure J. The impact of oxytocin on food intake and emotion recognition in patients with eating disorders: a double blind single dose within-subject cross-over design. PLoS One. 2015 Sep 24;10(9):e0137514. doi:10.1371/journal.pone.0137514. eCollection 2015.
49.    Welch MG, Margolis KG, Li Z, Gershon MD. Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G848–G862.
50.    Murrell TG. The potential for oxytocin (OT) to prevent breast cancer: a hypothesis. Breast Cancer Res Treat. 1995 Aug;35(2):225–229.
51.    Sato W, Kochiyama T, Uono S, et al. The structural neural substrate of subjective happiness. Sci Rep. 2015;5:16891.
52.    Vaccari C, Lolait SJ, Ostrowski NL. Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain. Endocrinology. 1998 Dec;139(12):5015–5033.

Dr. BerksonDr. Devaki Lindsey Berkson has been a chiropractor, distinguished estrogen scholar at Tulane, medical nutritionist, and scientist, and has had the good fortune to work in team medical practices for over three decades. She has been able to apply the research that fate has allowed her to learn and sleuth, starting with a rotation in integrative medicine and endocrinology with Dr. Jonathan Wright in 1977. She presently teaches CME courses for MDs, pharmacists, NDs, chiropractors, and acupuncturists as well as the public. She has published peer-reviewed original dialysis research, coinvented a botanical/pharmaceutical drug, and is a thought leader in functional medicine with an emphasis on nutritional gastroenterology and endocrinology. She authored the best-selling book on the gut/body/mind/nutrition link (Healthy Digestion the Natural Way; Wiley), a breakthrough book on endocrine disruption (Hormone Deception; McGraw-Hill), a book on the science behind bioidentical hormones (Safe Hormones, Smart Women; Awakened Medicine), the only nutrition/hormone female reference book (Natural Answers for Women; Simon & Schuster), and a family guide for good eating with lots of pictures for the kids (Retraining Your Tongue; Awakened Medicine). And more! Devaki is appreciated for combining evidence-based science with unabashed humor. She is soon launching teaching modules.

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