Fibromyalgia
and Sensory-Motor Conflict
A pre-existing sensory-motor conflict may contribute to the pain
and sensory perceptions reported by people with fibromyalgia syndrome
(FMS), according
to a study by C.S. McCabe, H. Cohen, and D.R. Blake (Rheumatology.
2007; 46(10): 1587-1592). McCabe and colleagues created motor-sensory conflict
in 29 adults with fibromyalgia by having them perform congruent/incongruent
limb movements with one limb hidden behind a mirror, set at a right angle
to the subject's body. Results from this cohort were compared to data
from a previous cohort of age- and gender-matched healthy volunteers. McCabe
and colleagues performed the study to explore the hypothesis that "symptoms
of FMS arose from ‘central neuromodulatory disregulation' evident
by augmented pain processing."
In the Rheumatology study, the researchers
asked the FMS subjects to move the limb that they could see parallel to
a marker and then move the hidden
limb
in a position that matched the other. (Subjects had been told that the study
was assessing limb position sense.) The researchers then asked open-ended
questions such as, "How did that feel?" and "Were you aware of any
changes in either limb?" Twenty-six of the 29 FMS participants reported
sensory effects, including disorientation, pain, and perceived changes in
temperature, limb weight, or body image. They also said that the feelings
were very similar
to the symptoms that occur during FMS flare-ups.
"In conclusion," the authors write, "we would propose that
sensory-motor conflict may perpetuate some of the somaesthetic disturbances reported
in FMS. This may occur either because an individual has an innate vulnerability
to sensory-motor disturbances and/or they develop a heightened awareness, or
reduced threshold, to the daily minor sensory changes that are generated when
predicted sensory feedback does not match actual." An autonomic stress
response due to the perceived conflict may provide additional fuel to the conflict.
McCabe CS, Cohen H, Blake DR. Somaesthetic disturbances in fibromyalgia are
exaggerated by sensory-motor conflict: Implications for chronicity of the
disease? Rheumatology. September 1, 2007;
46(10):1587-1592. Available at: http://rheumatology.oxfordjournals.org/cgi/content/full/46/10/1587.
Accessed November 21, 2007.
Fibromyalgia and Intravenous Micronutrient
Therapy (Myers' Cocktail)
David Katz, MD, director of the Integrative Medicine Center at Griffin
Hospital (Derby, Connecticut), has been investigating the use of
intravenous micronutrient
therapy (IVMT) to help people with fibromyalgia. Under his lead, the Yale-Griffin
Prevention Research Center initiated a National Center for Complementary
and Alternative Medicine-sponsored study of IVMT in 2004. IVMT, also known
as Myers' cocktail, is a high-dose combination of B-complex, vitamin
C, magnesium, and calcium given in a slow intravenous drip, allowing for
greater absorption than is possible with oral supplements. John Myers, a
Baltimore doctor, began using a similar intravenous "cocktail" in
the 1960s to help patients with fatigue, depression, chest pain, and other
problems. Alan Gaby, MD, took on the care of some of Dr. Myers' patients
after his death in 1984. Dr. Myers did not leave printed information about
his formula, so Dr. Gaby researched and formulated his own version based
on what was known about the original.
Dr. Katz says that about 80% of his fibromyalgia patients benefit from
IVMT with "about one in five" feeling better after the first treatment.
Most patients experience changes by the fourth or fifth treatment. IVMT does
not make the pain go away forever, but it does provide short-term relief: "A
lot of patients come back within a month, saying their symptoms are starting
to recur…." Dr. Katz does not recommend IVMT for people with
medical conditions that may react negatively to IVs or extra fluid, e.g.,
blood disorders
such as hemophilia, or kidney disease, or congestive heart failure.
Arnold J. Spotlight on fibromyalgia. Alternative
Medicine. February 2005:31-34.
Katz D. The Promise and Pitfalls of Intravenous Micronutrient Therapy: From
Practice to Theory and Back Again. (Power Point presented at ACAM Conference
in Dallas, Texas, May 4, 2006). Available at: http://davidkatzmd.com/media/IVMT.Katz.5-06.ppt#297,38,Bibliography,cont.
Accessed November 21, 2007.
(Note: The PowerPoint begins at http://davidkatzmd.com/media/IVMT.Katz.5-06.ppt, 153KB)
Cognitive Behavior Therapy, Exercise, and CFS/FM
Cognitive behavior therapy (CBT) helps people with chronic fatigue syndrome
(CFS; a.k.a. myalgia encephalomyelitis) and fibromyalgia learn how to pace
their activities and develop an accurate perspective of their energy levels.
People with these conditions often live in fear that symptoms will flare.
That fear can incapacitate them. CBT therapists teach patients self-help
strategies that let them gain some control over their symptoms. CBT strategies
include keeping an energy diary that tracks symptoms, energy level changes,
and activities; doing relaxation exercises and meditation; finding ways to
promote better sleep; prioritizing and delegating tasks; learning flexibility;
pacing daily activities; and performing gentle physical exercise.
CBT is very controversial among the CFS/FM community because some practitioners
have pointed to its effectiveness in clinical studies as evidence that the
illness stems from "wrong thinking." Such practitioners use graded
exercise therapy (GET) in their CBT programs. GET assumes that CFS/FM symptoms
have no physiological cause, that "deconditioning, depression, and believing
one is ill are at the root of CFS," according to Moira Smith. Graded
exercise therapy encourages patients to stick to ever-increasing exercise
goals, like an athlete in training. In reality, CFS/FM symptoms vary from
day to day.
Trying to stick to an inflexible schedule may compound the problem. Interestingly,
the clinical studies that recommend CBT/GET as an effective treatment rarely
include the most disabled and tend to have high drop-out rates.
Pacing, on the other hand, acknowledges a biological dysfunction and recognizes
that a relapse will occur if patients overextend their energy. "Pacing," Moira
Smith explains, "is all about ‘listening to your body' (instead
of your conscience or other people) and accepting that this means your activity
levels will vary a lot." Cognitive behavior therapy that uses pacing
strategies helps patients learn how to work with their energy levels instead
of pushing themselves to the point of symptom flare-ups and disability.
Carruthers, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: clinical
working case definition, diagnostic and treatment protocols. Journal
of Chronic Fatigue Syndrome. 2003; 11(1): 46-49. Available at: http://cfids-cab.org/MESA/ccpc-1.html.
Accessed November 22, 2007.
Parks R. Cognitive-behavioral therapy for chronic fatigue syndrome. WebMD.
May 15, 2007. Available at: www.webmd.com. Accessed November 8, 2007.
Smith M. Pacing and graded exercise compared. Available at http://mecfscanberra.org.au/docs/pacing.htm.
Accessed November 8, 2007.
Stulemeijer M, de Jong LWAM, Fiselier TJW, et al. Cognitive behaviour therapy
for adolescents with chronic fatigue syndrome: randomized controlled trial.
BMJ. January 1, 2005;330(14). Available at: www.bmj.com/cgi/content/full/330/7481/14?etoc.
Accessed November 8, 2007.
Chronic Fatigue Syndrome and Abnormal Heart Function
An August 2003 study, performed by Arnold Peckerman, PhD, and colleagues, found
a correlation between poor cardiac function and symptom severity in people
with chronic fatigue syndrome (CFS). In this study, the authors explain that
previous research had identified circulatory-related problems in CFS patients
such as autonomic dysfunction, lower plasma volume and/or red cell mass,
neurohormonal abnormalities that affect circulation, post-exercise reduction
in brain blood flow (using nuclear imaging), and reduced blood flow in exercising
muscles (using magnetic resonance spectroscopy). This information caused
Dr. Peckerman and colleagues to hypothesize that people with CFS have reduced
cardiac output. They collected symptom data and measured cardiac output using
impedance cardiography in 38 people with CFS and 27 matched, sedentary controls.
In Peckerman's study, heart stroke volume and cardiac output were significantly
lower in 18 of 38 CFS patients. These patients also reported the most severe
symptoms (ratings = three on a scale of zero to five). They had a higher percentage
of severe ratings for post-exertional fatigue, joint pain, headache, swollen
lymph nodes, fever-chills, and sore throat, compared to the remaining CFS patients
and controls. The study's authors report that "post-exertional
fatigue and flu-like symptoms…were predictive of lowered cardiac output
(p<0.0002)….neuropsychiatric symptoms showed no specific association
with cardiac output." Heart rate and mean arterial blood pressure were
similar in the three groups.
In an interview conducted by Mark Giuliucci, Dr. Peckerman explains that CFS
patients do not show the clinical signs of hypoperfusion, in which cardiac
output cannot meet metabolic demand. Nonetheless, he believes that the reduced
blood flow found in CFS patients may have clinical significance. Dr. Peckerman
took part in another study that used cardiac stress testing. Preliminary evidence
from that test indicates that some CFS patients have heart failure.
Why do some people with CFS develop heart failure? Dr. A. Martin Lerner believes
that chronic mononucleosis infection in the heart leads to left-ventricular
dysfunction in a large subset of CFS patients. Dr. Lerner owns "U.S.
patents for the diagnosis of ME/CFS in the chronic mononucleosis subset of
this disease using 24-hour Holter monitoring," according to Myalgic Encephalomyelitis
Society of America. Paul Cheney, MD, PhD, hypothesizes that mitochondrial dysfunction
and low ATP energy in the heart, not chronic infection in itself, lead to diastolic
cardiomyopathy. "Many of the symptoms of CFS could be explained by heart
failure…," Dr. Sarah Myhill writes in her explanation of Dr. Cheney's
mitochondrial hypothesis. "Cardiologists and other doctors are used to
dealing with heart failure due to poor blood supply to the heart itself. In
CFS, the heart failure is caused by poor muscle function…." Mitochondria,
including those in the heart's cells, are simply not producing enough
energy (ATP).
Denoon D. Abnormal heart pumping after exercise linked to chronic fatigue
syndrome. WebMD Medical News. April 14, 2003. Available at: www.webmd.com/news/20030414/tricky-heart-may-cause-chronic-fatigue.
Accessed November 21, 2007.
Giuliucci M. Cardiac output linked to severe CFS cases. Available at: www.cfids.org/archives/2003rr/2003-rr2-article01.asp.
Accessed November 26, 2007.
Myalgic Encephalomyelitis Society of America. Cardiac insufficiency hypothesis.
Available at: www.cfids-cab.org/MESA/Lerner.html. Accessed November 21, 2007.
Myhill S. CFS is heart failure secondary to mitochondrial malfunction. Available
at: www.drmyhill.co.uk/article.cfm?id=373. Accessed November 21, 2007.
(March 2008: Above link does not work. Use: http://www.chronicfatiguesupport.com/library/showarticle.cfm/id/7495)
Peckerman A, Lamanca JJ, Dahl KA, et al. Abnormal impedance cardiography
predicts symptoms severity in chronic fatigue syndrome. The
American Journal of the Medical Sciences. August 2003: 326(2):55-60.
Available at www.cfids-cab.org/MESA/Peckerman.pdf.
(283KB .pdf) Accessed November 26, 2007.
RNase L Pathway and CFS
Paul Cheney, MD, PhD, believes that abnormalities in the RNase L
pathway, first reported by R. J. Suhadolnik and colleagues (Clin
Infect Dis. 1994 Jan; 18
Suppl 1:S96-104) may explain the progression of chronic fatigue syndrome
(CFS). RNase L destroys all cellular and viral RNA within a cell. All viruses,
particularly herpes virus (e.g., Epstein-Barr, cytomegalovirus) and intracellular
bacteria (e.g., Mycoplasma and Chlamydia pneumoniae), stimulate RNase L
activity. In people with CFS, RNase L is more active than in healthy
controls. In addition,
the level of bioactive 2-5A (the molecule that "turns on" RNase
L) is higher and the level of latent 2-5A is lower than in controls. Researchers
have also identified a more potent form of RNase L in CFS patients that
is less than half the normal molecular weight of 80 kilodaltons (kDa).
Studies
have linked these abnormalities to impaired health.
Dr. Cheney hypothesizes that CFS moves through three distinct stages that
begin when an intracellular organism activates the RNase L pathway. Normally,
the
immune system attacks viral pathogens after RNase L prohibits viral replication;
then all systems downgrade to normal. In people with CFS, however, RNase
L changes into the lower- weight, more potent form, and the pathway remains
activated
longer. Abnormal RNase L damages liver enzymes necessary for detoxification.
Phase II of CFS, according to Dr. Cheney, occurs when the liver's ability
to remove toxins from the blood becomes impaired. "[The shift from Phase
I to Phase II] usually sounds like this," says Dr. Cheney. "'You
know, I felt like I had the flu or mono, and then my disease changed. The sore
throats went away, the glands got better, the fever came down – but now
I'm even sicker. My basic problem now is that I can't think anymore.
My fatigue is worse than ever. And I'm beginning to hurt – a lot.'" The
amount of pain depends upon the toxins involved, according to Dr. Cheney. Toxins
can also inhibit liver enzymes. After a time, circulating toxins injure the
hypothalamus and other brain structures, leading to Phase III. At this point, "dynamic
hormone response" (ability to respond to signals for more or less hormone
activity) becomes impaired. Toxins may also damage mitochondria (which produce
cellular energy). As a result, patients at Phase III cannot cope with too
much stress; they must maintain a restricted sphere of activity to function.
A beginner's guide to the RNase L pathway. Available at: http://freespace.virgin.net/david.axford/rnase-l.htm.
Accessed November 12, 2007.
Englebienne P. RNase L in health and disease: what did we learn recently?
Journal of Chronic Fatigue Syndrome. 2003;11(2):97-109. Available at: www.immunesupport.com/library/print.cfm?ID=5116&t=CFIDS_FM.
Accessed November 12, 2007.
RNase L. Wikipedia. Available at http://en.wikipedia.org/wiki/RNase_L. Accessed
November 12, 2007.
Sieverling C. The three phases of chronic fatigue syndrome: dr. paul cheney's
theory. Available at: www.immunesupport.com/library/print.cfm?ID=3999&t=CFIDS_FM.
Accessed November 8, 2007.
Suhadolnik RJ, Reichenbach NL, Hitzges P, et al. Upregulation of the 2-5A synthetase/RNase
L antiviral pathway associated with chronic fatigue syndrome (Abstract). Clin
Infect Dis. 1994 Jan; 18 Suppl 1:S96-104. Available at: www.ncbi.nlm.nih.gov.
Accessed November 21, 2007.
The Council on Wireless Technology Impacts
Because we cannot see or feel electromagnetic radiation, most of
us do not give its effects a second thought. Yet, electromagnetic
fields (EMF) do affect
biology. Widespread use of mobile and cell phones, computers, and other
electronic devices generates EMF in amounts previously unknown
to biological systems.
The Council on Wireless Technology Impacts and Ecological Options Network
has produced a DVD that documents California activists' attempts
to restrict cell phone towers and WI-FI (wireless computer systems) and
educates
viewers about EMF effects.
The first documentary on this DVD, Public Exposure: DNA, Democracy and
the "Wireless
Revolution," focuses on Californians' uphill battle to restrict
the placement of cell phone towers and to educate legislators about the effects
of EMFs. The US Telecommunications Act of 1996 prevents state and local governments
from blocking cell towers because of health concerns. This 59-minute documentary
also contains interviews with Swedish scientists and participants of the
June 2000 International Conference on Cell Phone Tower Siting (Salzburg,
Austria).
Sweden is more advanced in its recognition of electrosmog than the US. Stockholm,
considered "the Silicon Valley of Europe," is dependent on its
telecommunications industry. Unlike the US, however, profits do not blind the
Swedish government to the biological effects of EMF. The Swedish government
has accepted electro-sensitivity as a reason for disability. Two percent of
the Swedish population are electrosensitive, according to official statistics.
Dr. Olle Johansson, a neuroscientist at Sweden's Karolinska Institute,
explains that double-blind studies have shown that EMF sensitivity exists;
people are not making up symptoms or talking themselves into having symptoms.
Per Segerbeck, also interviewed in the documentary, is a senior electronics
engineer who became electro-sensitive in the early 1990s. He says that 80 to
90% of his work team also became hypersensitive to EMF within a year, after
working about 40-50 yards from a bay of mobile antennae. Segerbeck must wear
a HazMat suit with steel fibers to protect himself from microwave radiation
while going to and from work. If he doesn't, he becomes unconscious within
ten minutes of exposure. The international segment of Public Exposure was the
most interesting part to me. Except for the scientists at the Salzburg conference,
this documentary lacks details about EMF's health effects, portraying
instead public fears and activists' interaction with government.
The second presentation on this DVD, however, makes up for Public Exposure's
lack of scientific detail. Electromagnetic Fields is a 25-minute presentation
by Dr. Ted Litovitz, made before Congressional staff on July 12, 2001. Dr.
Litovitz, a physicist and EMR researcher, directed the BioElectromagnetics
Laboratory at Catholic University of America before his death in May 2006.
In the film, he explains that today's EMF safety standards are based
on its thermal effects – its ability to heat biological tissue. Published
studies, however, have documented biological effects at exposure levels far
below radiofrequency radiation (RFR) signal strength that government agencies
deem safe. The standard RFR for a cell phone is 1.6 watts/kg of body weight.
Studies show RFR affects the immune system at 0.015 watts/kg, increases calcium
ion efflux (flow out of cells) at 0.005 watts/kg, induces DNA damage at 0.0024
watts/kg, affects blood/brain barrier at 0.0004 watts/kg, and enhances cell
proliferation at 0.000021 watts/kg. Dr. Litovitz says that genetics affects
a person's susceptibility to RFR exposure, just as genetics affect a
person's reaction to pharmaceuticals. He does not view all EMF radiation
as being hazardous to health. "Everything is a poison. It is only a question
of dose," Dr. Litovitz says, quoting Paracelsus. "Weak electromagnetic
fields can induce non-thermal biological effects. They can be adverse. They
can be beneficial. They can be inconsequential. It is only a question of
dose. To protect public health, we must determine the allowable dose for
each of
the above conditions."
The Council on Wireless Technology Impacts has Dr. Litovitz's presentation
available online (www.energyfields.org). The DVD containing both productions
is also available from that site for $25 (US)/ $30 (Canada). Contact films@energyfields.org for more information.
The Council on Wireless Technology Impacts. Public Exposure (DVD) Novato, California;
2001. Available at: http://energyfields.org.
The Council on Wireless Technology Impacts. Electromagnetic Fields (DVD). Novato,
California, 2007. Available at: http://energyfields.org.
Cox S. Are your cell phone and laptop bad for your health? AlterNet. July 31,
2007. Available at: www.truthout.org/docs_2006/printer_092807P.shtml. Accessed
September 28, 2007.
Ribose for Chronic Fatigue Syndrome
In 2006, Jacob Teitelbaum, MD, and Valen Labs released the results of a study
that looks at the effect of D-ribose on people with fibromyalgia (FM) and
chronic fatigue syndrome (CFS) (J Altern Complement Med. 2006 Nov;12(9):857-62).
D-ribose is the sugar that mitochondria use to make ATP (cellular energy).
Usually, the body makes plenty of ribose from glucose. People with CFS/FM,
however, may not be able to convert enough because of a lack of cellular
energy, according to Dr. Sarah Myhill.
In this open-label, feasibility study, 41 people with FM and/or CFS took
five grams of D-ribose (CORvalen™), three times a day for a total
of 280 grams. Patients completed questionnaires before and after the treatment
period. About
66% of the participants reported improvement, not cure, in their symptoms.
Average energy levels increased from 3.8 to 5.5 on a scale of 1-to-10 (about
45%). Sleep, mental clarity, pain intensity, and well-being average ratings
also showed improvement. Dr. Teitelbaum says that patients must take five
grams, three times a day, for at least the first three weeks for the supplement
to
be effective. A CORvalen representative told Cort Johnson that patients can
cut back to five grams, twice a day, after a month if they want. As with
many supplements, it can take several weeks for patients to notice an effect.
CORvalen™ (D-Ribose) improves pain and quality of life in fibromyalgia
and chronic fatigue patients. Medical News Today. February 9, 2006. Available
at: www.medicalnewstoday.com. Accessed November 8, 2007.
Johnson C. D-Ribose treatment of chronic fatigue syndrome. Available at: www.ei-resource.org/articles/chronic-fatigue-syndrome-articles/d%11ribose-treat-of-chronic-fatigue-syndrome/.
Accessed November 8, 2007.
Myhill S. CFS is heart failure secondary to mitochondrial malfunction. Available
at www.cfids-cab.org/MESA/DrMyhill-373.pdf.
(102 KB) Accessed November 21, 2007.
Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue
syndrome and fibromyalgia: a pilot study (Abstract). J
Altern Complement Med.
2006 Nov;12(9):857-62. Available at: www.ncbi.nlm.nih.gov. Accessed November
8, 2007.
Minocycline and Strokes
Minocycline, an antibiotic and antiprotozoal, appears to protect
against stroke damage in humans, according to an Israeli study
published in Neurology (October
2, 2007). The antibiotic produced significant neuroprotective effects in
earlier studies involving animal models of multiple sclerosis, Parkinson's
disease, Huntington's disease, amyltrophic lateral sclerosis, and stroke.
To see if minocycline has a similar effect in humans, the Israeli research
team performed a randomized, open-label study on patients arriving at an
emergency department too late for tissue-plasminogen activator to be effective.
One group received 200 mg of minocycline orally for five days, and the other
got a placebo, beginning six to 24 hours after stroke onset. Blinded evaluators
used the National Institutes of Health Stroke Scale, modified Rankin Scale,
and Barthel Index to measure outcomes at baseline, days 7, 20, and 90. Results
showed a clear benefit. The final mean NIHSS score in the minocycline group
was 1.6 (little or no disability) compared to the placebo group's
6.5 (near upper limit for mild disability).
"The improvement was already apparent within a week of the stroke," said
study author Yair Lampl, MD, in a statement from the American Academy of Neurology. "This
is exciting because many people who have had a stroke cannot be treated if they
don't get to the hospital within three hours after symptoms start, which
is the time frame for currently available treatments." Minocycline treatment
in this study did not correlate with a lower risk of death, myocardial infarction,
recurrent strokes, or hemorrhagic transformation. The researchers call for
a larger double-blind study to confirm their results and to determine the most
effective dosage and the best time to start treatment.
The ALS Association. Phase III Trial of Minocycline. Available at: www.alsa.org/patient/drug.cfm.
Accessed November 8, 2007.
Antibiotic, minocycline, may reduce stroke damage, study suggests. AMA Member
Communications. October 2, 2007.
Jeffrey S. Minocycline may improve stroke outcomes out to 24 hours. Medscape
Medical News 2007. October 1, 2007. Available at: www.medscape.com. Accessed
November 8, 2007.
National Institute of Neurological Disorders and Stroke. Minocycline Information
Summary. Available at: www.ninds.nih.gov. Accessed November 8, 2007.
Osterweil N. Minocycline reduces stroke damage in late-presenting patients.
Medpage Today. October 1, 2007. Available at: www.medpagetoday.com/Neurology/Strokes/tb/6835.
Accessed November 8, 2007.
DMSO
Dimethyl sulfoxide (DMSO), a by-product of paper manufacturing, is
a powerful solvent that has several physiological effects. It relieves
pain, reduces
inflammation, softens scar tissue, increases vasodilation, and increases
hydroxyl radical scavenging. US investigation of its therapeutic possibilities
began in the early 1960s. Robert Herschler, PhD, a researcher at Crown
Zellerbach, and Stanley Jacob, MD, who taught at Harvard Medical
School at the time,
collaborated on research involving DMSO's ability to relieve arthritic
pain and inflammation. They also investigated ways to use the solvent for
drug-delivery. DMSO easily penetrates the skin, and any substance that
comes in contact with this solvent will also be carried into the body.
FDA interest
in DMSO as a therapeutic agent ended in 1965, after the death of an Irish
woman who had received DMSO for a sprained wrist. No autopsy was performed
on the woman. Some believe that she had an allergic reaction to the solvent,
but the actual cause of death is unknown. The agency did, however, approve
its use to treat interstitial cystitis (a very painful, chronic bladder
inflammation) in 1978. Also, US veterinarians use DMSO to treat musculoskeletal
disorders
in dogs and horses. Elsewhere, Dutch physicians use DMSO to relieve the
pain of reflex sympathetic dystrophy, and many Russian doctors use it to
treat
arthritis.
Over the years, Dr. Stanley has used a mixture of DMSO and DMSO2 (intravenous,
oral, and topical) to help people with fibromyalgia. He estimates that 70%
of his fibromyalgia patients experienced improvement after about two months.
Dr. Stanley is now investigating DMSO's effect on closed head trauma,
including traumatic brain injury and stroke. Intravenous DMSO reduced swelling,
caused by head injury, within five minutes in early studies (1978 to 1982).
DMSO has no known serious side effects, although a serious allergic reaction
is possible. D.W. Gregg says, "Start with one drop and if there is any
allergic reaction, don't use it at all." Garlicky breath odor,
occasional nausea or drowsiness, and temporary itching, flaking, and burning
at the application site are more common side effects. I know of one case
in which a nasty, itchy rash developed when it was applied, then covered
by polyester
sweat pants.
Most veterinary DMSO and over-the-counter products are industrial grade and
vary in quality. Pharmaceutical-grade DMSO is available by prescription only.
Gregg DW. DMSO and MSM: The biochemical oxygen transport pair. Available at:
www.krysalis.net/dmso.htm. Accessed November 8, 2007.
Jacob SW. Current Status of DIMETHYL SULFOXIDE (DMSO). March 2002. Available
at: www.dmso.org/articles/information/pjacob.htm. Accessed November 8, 2007.
Kovach S. The untapped healing potential of DMSO. LIFE
EXTENSION. July 2007;63-68
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