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From the Townsend Letter
December 2013

Efficacy of Benfotiamine in the Management of Glycation
by Gaetano Morello, ND
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Notes
1.   Goldberg T, Cai W, Peppa M. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc. 2004 Aug;104(8):1287–1291.
2.   Yamagishi S. Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp Gerontol. 2011 Apr;46(4):217–224.
3.   Peppa M, Uribarri J, Vlassara H. Glucose, advanced glycation end products, and diabetes complications: what is new and what works. Clinical Diabetes. Oct 2003;21(4):186–187.
4.   Hegab Z, Gibbons S, Neyses L, Mamas MA. Role of advanced glycation end products in cardiovascular disease. World J Cardiol. 2012 April 26; 4(4):90–102.
5.   Baumann M. Role of advanced glycation end products in hypertension and cardiovascular risk: human studies. J Am Soc Hypertens. 2012 Nov;6(6):427–435.
6.   Hartog JW, Voors AA, Bakker SJ, Smit AJ, van Veldhuisen DJ. Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications. Eur J Heart Fail. 2007 Dec;9(12):1146–1155.
7.   Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, Thornalley PJ. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes. 2003;52(8):2110–2120.
8.   Lin J, Alt A, Liersch J, Bretzel RG, Brownlee M, Hammes H-P. Benfotiamine inhibits intracellular formation of advanced glycation end products in vivo. Available at: http://benfotiamine.org/Benfo600Study.pdf. Accessed April 27, 2013.
9.   Stirban A, Negrean M, Stratmann B, et al. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care. 2006;29(9):2064–2071.
10. Stirban A, Negrean M, Stratmann B, et al. Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method. Diabetes Care. 2007;30(10):2514–2516.
11. Haupt E, Ledermann H, Köpcke W. Benfotiamine in the treatment of diabetic polyneuropathy–a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005;43(2):71–77.
12. Shinde Urmila A, Sharma G, Xu Yan J, Dhalla Naranjan S, Goyal Ramesh K. Anti-diabetic activity and mechanism of action of chromium chloride. Exp Clin Endocrinol Diabetes. 2004 May;112(5):248–252.
13. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006 Dec;8(6):636–643.
14. Geohas J, Daly A, Juturu V, Finch M, Komorowski JR. Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci. 2007 Mar;333(3):145–153.
15. Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR. Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial. J Cardometab Syndr. 2007 Spring;2(2):91–97.
16. Gayova E, Kron I, Suchozova K, Pavlisak V, Fedurco M, Novakova B. Carnosine in patients with type I diabetes mellitus. Bratisl Lek Listy. 1999 Sep;100(9):500–502.
17. Korobov VN, Maurisio RB, Mukalov IO, Stvolinskii SL. Carnosine stabilization of the normal erythrocyte membranes and in experimental diabetes. Patol Fiziol Eksp Ter. 2000 Apr–Jun;(2):13–15.
18. Rashid I, van Reyk DM, Davies MJ. Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Lett. 2007 Mar 6;581(5):1067–1070.
19. Alhamdani MS, Al-Azzawie HF, Abbas FK. Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptides. Perit Dial Int. 2007 Jan–Feb;27(1):86–89.
20. Gugliucci A, Kotani K, Taing J, et al. Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults. Ann Nutr Metab. 2009;54(3):197–201.
21. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010 Jun;110(6):911–916.
22. Boor P, Celec P, Behuliak M, Grancic P, et al. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism. 2009 Nov;58(11):1669–1677.

Dr. Gaetano MorelloDr. Gaetano Morello is a naturopathic physician practicing in West Vancouver, Canada. He received his bachelor of science degree from the University of British Columbia and his doctor of naturopathic medicine from Bastyr University of Natural Health Sciences in Seattle, Washington. Since 1991, Dr. Morello has been training and educating physicians, pharmacists, and health experts on the scientific use of natural medicines in the fields of cardiology, immunology, gastroenterology, anti-aging, and detoxification. Contributing author to the authoritative text on Alternative Medicine, A Textbook of Natural Medicine, he is also author of The Fiber Miracle. Lecturer and regular contributor to a number of magazines, journals, and publications, Dr. Morello has hosted and appeared on numerous television and radio shows discussing the power of natural medicine. In 2013, Dr. Morello joined the newly created Complex Chronic Disease Program located at BC Women's Hospital & Health Centre.

His publications include The Cleanse, Ultimate Inside Out Approach, Whole Body Cleansing, Transform your Health, Fiber Wonder, and Probiotic Breakthrough, and a contribution to A Textbook of Natural Medicine. Dr. Morello has also written hundreds of articles.

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